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Immunologic changes after diode laser inferior turbinoplasty in allergic rhinitis

The Egyptian Journal of Otolaryngology volume 32, pages 141–146 (2016)Cite this article

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Abstract

Objectives

It was suggested previously that turbinoplasty by laser improves the symptomatology of allergic rhinitis (AR) not only by a mechanical effect but also by inhibiting the local allergic reaction at the level of the inferior turbinates. The aim of this study was to determine whether the short-term immunologic effects of diode laser, when used to perform inferior turbinoplasty in AR, can also be detected at the systemic level.

Patients and methods

Twenty patients, seeking a treatment by laser for AR manifestations refractory to local and systemic medical therapy, were included in a prospective study. Blood picture, total immunoglobulin E, interleukin (IL)-4, IL-5, and interferon-γ levels were assessed immediately before and 1 month after diode laser inferior turbinoplasty (DLIT).

Results

One month after DLIT, the total leukocytic count increased with relative eosinopenia. Total immunoglobulin E and IL-5 decreased, together with insignificant changes in IL-4 and interferon-γ.

Conclusion

It is not impossible that DLIT modifies the clinical course of AR not only by a mechanical effect but also by its local or even by a systemic immunologic effect. The laser modulation of T-cell functions in the engorged turbinate submucosa is a plausible biomolecular interpretation of the observed effect.

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Authors and Affiliations

  1. Otolaryngology Unit, National Institute of Laser Enhanced Sciences, Cairo University, Giza, Egypt

    Hazem M. A. Saleh & Ahmed M. El-Kharbotly

  2. Department of Radiobiological Applications, Clinical Pathology Unit, Nuclear Research Center, Atomic Energy Authority, Egypt, Cairo

    Dalia R. Ibrahim, Michael I. Michael, Amal M. Kamal & Mervate M. Bahgat

Authors
  1. Hazem M. A. Saleh
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  2. Dalia R. Ibrahim
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  3. Michael I. Michael
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  4. Amal M. Kamal
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  5. Ahmed M. El-Kharbotly
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  6. Mervate M. Bahgat
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Correspondence to Hazem M. A. Saleh.

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Saleh, H.M.A., Ibrahim, D.R., Michael, M.I. et al. Immunologic changes after diode laser inferior turbinoplasty in allergic rhinitis. Egypt J Otolaryngol 32, 141–146 (2016). https://doi.org/10.4103/1012-5574.186535

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  • DOI: https://doi.org/10.4103/1012-5574.186535

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