Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z et al (2020) Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 395(10229):1054–1062
Article
CAS
Google Scholar
Wu Z, McGoogan J (2020) Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA 323(13):1239–1242
Article
CAS
Google Scholar
Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C et al (2020) Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med 8(4):420–422
Article
CAS
Google Scholar
Fang Y, Zhang H, Xie J, Lin M, Ying L, Pang P et al (2020) Sensitivity of chest CT for COVID-19: comparison to RT-PCR. Radiology. 296(2):E115–E117
Article
Google Scholar
Biadsee A, Biadsee A, Kassem F, Dagan O, Masarwa S, Ormianer Z (2020) Olfactory and oral manifestations of COVID-19: sex-related symptoms-a potential pathway to early diagnosis. Otolaryngol Head Neck Surg 163(4):722–728
Article
Google Scholar
Coelho D, Kons Z, Costanzo R, Reiter E (2020) Subjective changes in smell and taste during the COVID-19 pandemic: a national survey-preliminary results. Otolaryngol Head Neck Surg 163(2):302–306
Article
Google Scholar
Foster K, Jauregui E, Tajudeen B, Bishehsari F, Mahdavinia M (2020) Smell loss is a prognostic factor for lower severity of coronavirus disease 2019. Ann Allergy Asthma Immunol 125(4):481–483
Article
CAS
Google Scholar
Kanjanaumporn J, Aeumjaturapat S, Snidvongs K, Seresirikachorn K, Chusakul S (2020) Smell and taste dysfunction in patients with SARS-CoV-2 infection: a review of epidemiology, pathogenesis, prognosis, and treatment options. Asian Pac J Allergy Immunol 38(2):69–77
CAS
Google Scholar
Hummel T, Rothbauer C, Barz S, Grosser K, Pauli E, Kobald G (1998) Olfactory function in acute rhinitis a. Ann N Y Acad Sci 855(1):616–624
Article
CAS
Google Scholar
Bromley S (2000) Smell and taste disorders: a primary care approach. Am Fam Physician 61(2):427–436
CAS
Google Scholar
Schiffman S (1983) Taste and smell in disease. N Engl J Med 308(22):1337–1343
Article
CAS
Google Scholar
Boesveldt S, Postma EM, Boak D, Welge-Luessen A, Schöpf V, Mainland JD et al (2017) Anosmia-a clinical review. Chem Senses 42(7):513–523
Article
Google Scholar
Seiden AM, Duncan HJ (2001) The diagnosis of a conductive olfactory loss. Laryngoscope. 111(1):9–14
Article
CAS
Google Scholar
Fonteyn S, Huart C, Deggouj N, Collet S, Eloy P, Rombaux P (2014) Non-sinonasal-related olfactory dysfunction: a cohort of 496 patients. Eur Ann Otorhinolaryngol Head Neck Dis 131(2):87–91
Article
CAS
Google Scholar
Klopfenstein T, Zahra H, Lepiller Q, Royer P, Toko L, Gendrin V et al (2020) New loss of smell and taste: uncommon symptoms in COVID-19 patients in Nord Franche-Comte cluster, France. Int J Infect Dis 100:117–122
Article
CAS
Google Scholar
Abdelazim MH, Abdelazim AH (2022) Effect of sodium gluconate on decreasing elevated nasal calcium and improving olfactory function post COVID-19 infection. Am J Rhinol Allergy 36(6):841–848
Article
Google Scholar
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71
Article
Google Scholar
Wells GA, Shea B, O’Connell D, Peterson J, Welch V, Losos M et al (2011) The Newcastle-Ottawa scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Ottawa Hospital Research Institute, Ottawa Accessed at www.ohri.ca/programs/clinical_epidemiology/oxford.htm on 14 Nov 2012
Google Scholar
Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327(7414):557–560
Article
Google Scholar
Amanat M, Rezaei N, Roozbeh M, Shojaei M, Tafakhori A, Zoghi A et al (2021) Neurological manifestations as the predictors of severity and mortality in hospitalized individuals with COVID-19: a multicenter prospective clinical study. BMC Neurol 21(1):1–2
Article
Google Scholar
Avcı H, Karabulut B, Farasoglu A, Boldaz E, Evman M (2020) Relationship between anosmia and hospitalisation in patients with coronavirus disease 2019: an otolaryngological perspective. J Laryngol Otol 134(8):710–716
Article
Google Scholar
Porta-Etessam J, Núñez-Gil IJ, González García N, Fernandez-Perez C, Viana-Llamas MC, Eid CM et al (2021) COVID-19 anosmia and gustatory symptoms as a prognosis factor: a subanalysis of the HOPE COVID-19 (Health Outcome Predictive Evaluation for COVID-19) registry. Infection. 49(4):677–684
Article
CAS
Google Scholar
Petrocelli M, Cutrupi S, Salzano G, Maglitto F, Salzano FA, Lechien JR et al (2021) Six-month smell and taste recovery rates in coronavirus disease 2019 patients: a prospective psychophysical study. J Laryngol Otol 135(5):436–441
Article
CAS
Google Scholar
Talavera B, García-Azorín D, Martínez-Pías E, Trigo J, Hernández-Pérez I, Valle-Peñacoba G et al (2020) Anosmia is associated with lower in-hospital mortality in COVID-19. J Neurol Sci 419:117163
Article
CAS
Google Scholar
Yan CH, Faraji F, Prajapati DP, Ostrander BT, DeConde AS (2020) Self-reported olfactory loss associates with outpatient clinical course in COVID-19. Int Forum Allergy Rhinol 10(7):821–831
Article
Google Scholar
Vaira LA, Hopkins C, Salzano G, Petrocelli M, Melis A, Cucurullo M et al (2020) Olfactory and gustatory function impairment in COVID-19 patients: Italian objective multicenter-study. Head Neck 42(7):1560–1569
Article
Google Scholar
Carignan A, Valiquette L, Grenier C, Musonera JB, Nkengurutse D, Marcil-Héguy A et al (2020) Anosmia and dysgeusia associated with SARS-CoV-2 infection: an age-matched case–control study. CMAJ. 192(26):E702–E707
Article
CAS
Google Scholar
Beltrán-Corbellini Á, Chico-García JL, Martínez-Poles J, Rodríguez-Jorge F, Natera-Villalba E, Gómez-Corral J et al (2020) Acute-onset smell and taste disorders in the context of COVID-19: a pilot multicentre polymerase chain reaction based case-control study. Eur J Neurol 27(9):1738–1741
Article
Google Scholar
Symptoms of Coronavirus. US Centers for Disease Control and Prevention (2020). https://www.cdc.gov/coronavirus/2019-ncov/symptoms-testing/symptoms.html Published 2020. Accessed 25 May 2020.
Vaira LA, Hopkins C, Petrocelli M, Lechien JR, Soma D, Giovanditto F et al (2020) Do olfactory and gustatory psychophysical scores have prognostic value in COVID-19 patients? A prospective study of 106 patients. J Otolaryngol Head Neck Surg 49(1):56
Article
Google Scholar
Tong J, Wong A, Zhu D, Fastenberg J, Tham T (2020) The prevalence of olfactory and gustatory dysfunction in COVID-19 patients: a systematic review and meta-analysis. Otolaryngol Head Neck Surg 163(1):3–11
Article
Google Scholar
Klopfenstein T, Kadiane-Oussou N, Toko L, Royer P, Lepiller Q, Gendrin V et al (2020) Features of anosmia in COVID-19. Med Mal Infect 50(5):436–439
Article
CAS
Google Scholar
Moein S, Hashemian S, Mansourafshar B, Khorram-Tousi A, Tabarsi P, Doty RL (2020) Smell dysfunction: a biomarker for COVID-19. Int Forum Allergy Rhinol 10(8):944–950
Article
Google Scholar
Lechien J, Chiesa-Estomba C, De Siati D (2020) Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eur Arch Otorhinolaryngol 277(8):2251–2261
Article
Google Scholar
Hjelmesæth J, Skaare D (2020) Loss of smell or taste as the only symptom of COVID-19. Tidsskr Nor Laegeforen 140(7):1–5
Google Scholar
Hopkins C, Surda P, Kumar N (2020) Presentation of new onset anosmia during the COVID-19 pandemic. Rhinology. 58(3):295–298
Article
CAS
Google Scholar
Kaye R, Chang C, Kazahaya K, Brereton J, Denneny JC 3rd (2020) COVID-19 anosmia reporting tool: initial findings. Otolaryngol Head Neck Surg 163(1):132–134
Article
Google Scholar
Karimi-Galougahi M, Raad N, Mikaniki N (2020) Anosmia and the need for COVID-19 screening during the pandemic. Otolaryngol Head Neck Surg 163(1):96–97
Article
Google Scholar
Li Y, Bai W, Hashikawa T (2020) The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients. J Med Virol 92(6):552–555
Article
CAS
Google Scholar
Carod-Artal FJ (2020) Neurological complications of coronavirus and COVID-19. Rev Neurol 70(9):311–322
CAS
Google Scholar
Brann D, Tsukahara T, Weinreb C (2020) Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia. Sci Adv 6:eabc5801
Article
CAS
Google Scholar
Li Y, Bai W, Hirano N, Hayashida T, Hashikawa T (2012) Coronavirus infection of rat dorsal root ganglia: ultrastructural characterization of viral replication, transfer, and the early response of satellite cells. Virus Res 163(2):628–635
Article
CAS
Google Scholar
Huang C, Wang Y, Li X (2020) Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 395(10223):497–506
Article
CAS
Google Scholar
Wang D, Hu B, Hu C (2020) Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. JAMA. 323(11):1061
Article
CAS
Google Scholar
Chen N, Zhou M, Dong X (2020) Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 395(10223):507–513
Article
CAS
Google Scholar
Guan W, Ni Z, Hu Y (2020) Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 382(18):1708–1720
Article
CAS
Google Scholar
Wu C, Chen X, Cai Y (2020) Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern Med 180(7):934
Article
CAS
Google Scholar
Trigo J, García-Azorín D, Planchuelo-Gómez Á, Martínez-Pías E, Talavera B, Hernández-Pérez I et al (2020) Factors associated with the presence of headache in hospitalized COVID-19 patients and impact on prognosis: a retrospective cohort study. J Headache Pain 21(1):1
Article
Google Scholar
García-Azorín D, Martínez-Pías E, Trigo J, Hernández-Pérez I, Valle-Peñacoba G, Talavera B, Simón-Campo P et al (2020) Neurological comorbidity is a predictor of death in Covid-19 disease: a cohort study on 576 patients. Front Neurol 11:781
Article
Google Scholar
Silverberg JI, Zyskind I, Naiditch H, Zimmerman J, Glatt AE, Pinter A et al (2021) Association of varying clinical manifestations and positive anti–SARS-CoV-2 IgG antibodies: a cross-sectional observational study. J Allergy Clin Immunol 9(9):3331–3338
CAS
Google Scholar
Whitcroft K, Hummel T (2020) Olfactory dysfunction in COVID-19. JAMA. 323(24):2512
Article
CAS
Google Scholar
Birtay T, Bahadir S, Kabacaoglu E, Yetiz O, Demirci MF, Genctoy G (2021) Prognosis of patients hospitalized with a diagnosis of COVID-19 pneumonia in a tertiary hospital in Turkey. Ann Saudi Med 41(6):327–335
Article
Google Scholar
Lippi G, Plebani M (2020) Laboratory abnormalities in patients with COVID-2019 infection. Clin Chem Lab Med 58(7):1131–1134
Article
CAS
Google Scholar
Sanders JM, Monogue ML, Jodlowski TZ, Cutrell JB (2020) Pharmacologic treatments for coronavirus disease 2019 (COVID-19): a review. JAMA. 323(18):1824–1836
CAS
Google Scholar
Cooper KW, Brann DH, Farruggia MC, Bhutani S, Pellegrino R, Tsukahara T et al (2020) COVID-19 and the chemical senses: supporting players take center stage. Neuron. 107:219–233
Article
CAS
Google Scholar
Chen M, Shen W, Rowan NR, Kulaga H, Hillel A, Ramanathan M et al (2020) Elevated ACE-2 expression in the olfactory neuroepithelium: implications for anosmia and upper respiratory SARS-CoV-2 entry and replication. Eur Respir J 56(3):2001948
Article
CAS
Google Scholar
Fodoulian L, Tuberosa J, Rossier D, Boillat M, Kan C, Pauli V et al (2020) SARS-CoV-2 receptors and entry genes are expressed in the human olfactory neuroepithelium and brain. Iscience. 23(12):101839
Article
CAS
Google Scholar
Wang Z, Zhou J, Marshall B, Rekaya R, Ye K, Liu HX (2020) SARS-CoV-2 receptor ACE2 is enriched in a subpopulation of mouse tongue epithelial cells in nongustatory papillae but not in taste buds or embryonic oral epithelium. ACS Pharmacol Transl Sci 3:749–758
Article
CAS
Google Scholar
Agyeman A, Chin K, Landersdorfer C, Liew D, Ofori-Asenso R (2020) Smell and taste dysfunction in patients with COVID-19: a systematic review and meta-analysis. Mayo Clin Proc 95:1621–1631
Article
CAS
Google Scholar
Mao L, Jin H, Wang M, Hu Y, Chen S, He Q et al (2020) Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol 77:683–690
Article
Google Scholar
Paderno A, Schreiber A, Grammatica A, Raffetti E, Tomasoni M, Gualtieri T et al (2020) Smell and taste alterations in COVID-19: a cross-sectional analysis of different cohorts. Int Forum Allergy Rhinol 10(8):955–962
Article
Google Scholar
Sisó-Almirall A, Kostov B, Mas-Heredia M, Vilanova-Rotllan S, Sequeira-Aymar E, Sans-Corrales M et al (2020) Prognostic factors in Spanish COVID-19 patients: a case series from Barcelona. PLoS One 15(8):e0237960
Article
Google Scholar
Alizadehsani R, Alizadeh Sani Z, Behjati M, Roshanzamir Z, Hussain S, Abedini N et al (2021) Risk factors prediction, clinical outcomes, and mortality in COVID-19 patients. J Med Virol 93(4):2307–2320
Article
CAS
Google Scholar
Elimian KO, Ochu CL, Ebhodaghe B, Myles P, Crawford EE, Igumbor E et al (2020) Patient characteristics associated with COVID-19 positivity and fatality in Nigeria: retrospective cohort study. BMJ Open 10(12):e044079
Google Scholar