- Original Article
- Open Access
Correlation of immunoglobulin E levels and peripheral eosinophilia with paranasal sinus mucosal disease
The Egyptian Journal of Otolaryngology volume 29, pages 240–241 (2013)
The aim of this study was to assess whether total immunoglobulin E (IgE) levels and peripheral eosinophilia correlate with the extent of sinus mucosal disease on computed tomography (CT) of paranasal sinuses.
Patients and methods
CT scans were performed; total IgE and peripheral eosinophil levels were measured for all patients. The relationships between peripheral eosinophilia, total IgE levels, and the presence of mucosal disease on sinus CT imaging were also determined.
The total IgE did not correlate with CT stage of the disease, whereas there was a significant moderate positive correlation between CT stage and peripheral eosinophil levels.
The data suggest that eosinophil levels contribute toward mucosal inflammation in paranasal sinuses and the presence of peripheral eosinophilia in patients with sinusitis indicates a high likelihood of extensive disease. However, IgE levels did not correlate with CT scan findings. Calculation of the percentage of peripheral eosinophils by measurement of the differential leukocyte count is a simple, easy, and rapid technique for assessment of the severity of chronic rhinosinusitis.
Poznanovic SA, Kingdom TT. Total IgE levels and peripheral eosinophilia: correlation with mucosal disease based on computed tomographic imaging of the paranasal sinus. Arch Otolaryngol Head Neck Surg 2007;133:701–704.
Brook I. Bacteriologic features of chronic sinusitis in children. JAMA 1981;246:967–969.
Emanuel I, Shah S. Chronic rhinosinusitis: allergy and sinus computed tomography relationships. Otolaryngol Head Neck Surg 2000;23:687–691.
Eliashar R, Levi-Schaffer F. The role of the eosinophil in nasal disease. Curr Opin Otolaryngol Head Neck Surg 2005;13:171–175.
Newman L, Platts-Mills T, Phillips C, Hazen K. Chronic sinusitis. Relationship of computed tomographic findings to allergy, asthma and eosinophilia. JAMA 1994;271:363–367.
Lund VJ, Mackay IS. Staging in rhinosinusitis. Rhinology 1993;31:183–184.
Hoover G, Newman LJ, Platts-Mills TA, Phillips CD, Gross CW, Wheatley LM. Chronic sinusitis: risk factors for extensive disease. J Allergy Clin Immunol1997;100:185–191.
Baroody FM, Suh SH, Naclerio RM. Total IgE serum levels correlate with sinus mucosal thickness on computerized tomography scans. J Allergy Clin Immunol 1997;100:563–568.
Kountakis S, Arango P, Bradley E, Wade ZK, Borish L. Molecular and cellular staging for the severity of chronic rhinosinusitis. Laryngoscope 2004;114:1895–1905.
Conflicts of interest
There are no conflicts of interest.
About this article
Cite this article
Osman, M.M., Adballah, M. & Salem, M.A.M. Correlation of immunoglobulin E levels and peripheral eosinophilia with paranasal sinus mucosal disease. Egypt J Otolaryngol 29, 240–241 (2013). https://doi.org/10.7123/01.EJO.0000433258.24830.16
- chronic rhinosinusitis
- computed tomography scan
- immunoglobulin E