Skip to main content

Correlation of immunoglobulin E levels and peripheral eosinophilia with paranasal sinus mucosal disease




The aim of this study was to assess whether total immunoglobulin E (IgE) levels and peripheral eosinophilia correlate with the extent of sinus mucosal disease on computed tomography (CT) of paranasal sinuses.

Patients and methods

CT scans were performed; total IgE and peripheral eosinophil levels were measured for all patients. The relationships between peripheral eosinophilia, total IgE levels, and the presence of mucosal disease on sinus CT imaging were also determined.


The total IgE did not correlate with CT stage of the disease, whereas there was a significant moderate positive correlation between CT stage and peripheral eosinophil levels.


The data suggest that eosinophil levels contribute toward mucosal inflammation in paranasal sinuses and the presence of peripheral eosinophilia in patients with sinusitis indicates a high likelihood of extensive disease. However, IgE levels did not correlate with CT scan findings. Calculation of the percentage of peripheral eosinophils by measurement of the differential leukocyte count is a simple, easy, and rapid technique for assessment of the severity of chronic rhinosinusitis.


  1. Poznanovic SA, Kingdom TT. Total IgE levels and peripheral eosinophilia: correlation with mucosal disease based on computed tomographic imaging of the paranasal sinus. Arch Otolaryngol Head Neck Surg 2007;133:701–704.

    Article  Google Scholar 

  2. Brook I. Bacteriologic features of chronic sinusitis in children. JAMA 1981;246:967–969.

    Article  CAS  Google Scholar 

  3. Emanuel I, Shah S. Chronic rhinosinusitis: allergy and sinus computed tomography relationships. Otolaryngol Head Neck Surg 2000;23:687–691.

    Article  Google Scholar 

  4. Eliashar R, Levi-Schaffer F. The role of the eosinophil in nasal disease. Curr Opin Otolaryngol Head Neck Surg 2005;13:171–175.

    Article  Google Scholar 

  5. Newman L, Platts-Mills T, Phillips C, Hazen K. Chronic sinusitis. Relationship of computed tomographic findings to allergy, asthma and eosinophilia. JAMA 1994;271:363–367.

    Article  CAS  Google Scholar 

  6. Lund VJ, Mackay IS. Staging in rhinosinusitis. Rhinology 1993;31:183–184.

    CAS  PubMed  Google Scholar 

  7. Hoover G, Newman LJ, Platts-Mills TA, Phillips CD, Gross CW, Wheatley LM. Chronic sinusitis: risk factors for extensive disease. J Allergy Clin Immunol1997;100:185–191.

    Article  CAS  Google Scholar 

  8. Baroody FM, Suh SH, Naclerio RM. Total IgE serum levels correlate with sinus mucosal thickness on computerized tomography scans. J Allergy Clin Immunol 1997;100:563–568.

    Article  CAS  Google Scholar 

  9. Kountakis S, Arango P, Bradley E, Wade ZK, Borish L. Molecular and cellular staging for the severity of chronic rhinosinusitis. Laryngoscope 2004;114:1895–1905.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Mohamed M. Osman MD.

Additional information

Conflicts of interest

There are no conflicts of interest.

Rights and permissions

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Osman, M.M., Adballah, M. & Salem, M.A.M. Correlation of immunoglobulin E levels and peripheral eosinophilia with paranasal sinus mucosal disease. Egypt J Otolaryngol 29, 240–241 (2013).

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: