- Original Article
- Open access
- Published:
Effect of a prolonged topical glucocorticosteroid on interleukin-5 production and eosinophilic recruitment in the nasal submucosal compartment
The Egyptian Journal of Otolaryngology volume 29, pages 151–155 (2013)
En
Abstract
Aim
Intranasal corticosteroids offer effective treatment for allergic rhinitis. The action of interleukin 5 (IL-5) (Th2-type cytokine) and its response to intranasal steroids has not been thoroughly studied in the deep compartment of the nasal mucosa. The aim of this study was to determine the influence of prolonged topical glucocorticosteroid on the allergic inflammatory responses in the deep compartment of the nasal mucosa in patients with allergic rhinitis.
Materials and methods
Fluticasone furoate spray was used once daily. Biopsies were obtained from 22 patients with perennial allergic rhinitis at different intervals: before treatment with nasal corticosteroids, and after 1, 6, and 12 months. Biopsies were taken from 18 individuals serving as a control group. All biopsies were examined by light microscopy and immunohistochemisty.
Results
The results showed the efficacy of fluticasone in reducing the number of eosinophils in both epithelial and subepithelial layers, which suppresses the allergic manifestations. The maximum reduction occurred after 12 months. This is achieved by reducing the number of eosinophils and IL-5 in both epithelial and subepithelial compartments.
Conclusion
Intranasal corticosteroids effectively reduce both the number of eosinophils and IL-5 expression inside activated eosinophils. They influence both the epithelium and the deep compartment of the nasal mucosa.
References
Lim-Mombay M, Baroody F, Taylor R, Nacleri R. Mucosal cellular changes after nasal antigen challenge [abstract]. J Allergy Clin Immunol. 1992;89:A205.
Durham SR, Ying S, Varney VA, Jacobson MR, Sudderick RM, Mackay IS, et al. Cytokine messenger RNA expression for IL-3, IL-4, IL-5, and granulocyte/macrophage-colony-stimulating factor in the nasal mucosa after local allergen provocation: relationship to tissue eosinophilia. J Immunol. 1992;148:390–2394.
Baroody FM, Rouadi P, Driscoll PV, Bochner BS, Naclerio RM. Intranasal beclomethasone reduces allergen-induced symptoms and superficial mucosal eosinophilia without affecting submucosal inflammation. Am J Respir Crit Care Med. 1998;157 (3 part I): 899–906.
Igarashi Y, Goldrich MS, Kaliner MA, Irani A-MA, Schwartz LB, White MV. Quantitation of inflammatory cells in the nasal mucosa of patients with allergic rhinitis and normal subjects. J Allergy Clin Immunol. 1995;95:716–725.
Linden M, Svensson C, Andersson E, Andersson M, Greiff L, Persson CGA. Immediate effect of topical budesonide on allergen challenge-induced nasal mucosal fluid levels of granulocyte-macrophage colony-stimulating factor and interleukin-5. Am J Respir Crit Care Med. 2000;162:1705–1708.
Naclerio RM, Baroody FM, Kagey-Sobotka A, Lichtenstein LM. Basophils and eosinophils in allergic rhinitis. J Allergy Clin Immunol. 1994;94 (Suppl): 1303–1309.
Pipkorn U, Karlsson G, Enerback L. The cellular response of the human allergic mucosa to natural allergen exposure. J Allergy Clin Immunol. 1988;82:1046–1054.
Uller L, Emanuelsson CA, Andersson M, Erjefält JS, Greiff L, Persson CG. Early phase resolution of mucosal eosinophilic inflammation in allergic rhinitis. Respir Res. 2010;11:54–63.
Pipkorn U, Karlsson G, Enerback L. Nasal mucosal response to repeated challenges with pollen allergen. Am Rev Respir Dis. 1989;140 (3 I): 729–736.
Terada N, Konno A, Togawa K. Biochemical properties of eosinophils and their preferential accumulation mechanism in nasal allergy. J Allergy Clin Immunol. 1994;94 (Suppl): 629–642.
Bentley AM, Jacobson MR, Cumberworth V, Barkans JR, Moqbel R, Schwartz LB, et al.. Immunohistology of the nasal mucosa in seasonal allergic rhinitis: increases in activated eosinophils and epithelial mast cells. J Allergy Clin Immunol. 1992;89:877–883.
Andersson M, Andersson P, Venge P, Pipkorn U. Eosinophils and eosinophil cationic protein in nasal lavages in allergen-induced hyperresponsiveness: effects of topical glucocorticosteroid treatment. Allergy. 1989;44:342–348.
Tavernier J, Plaetink G, Guisez Y, Van der Heyden J, Kips J, Peleman R, et al. The role of interleukin 5 in the production and function of eosinophils. In: Whetton AD, Gordon J. Blood cell biochemistry. New York:Plenum Press; 1996. pp. 321–361.
Alam R, Sim TC, Hilsmeier K, Grant JA. Development of a new technique for recovery of cytokines from inflammatory sites in situ. J Immunol Methods. 1992;155:25–29.
Linden M, Svensson S, Anderson E, Andersson M, Greif L, Persson CG. Immediate effect of topical budesonide on allergen challenge-induced nasal mucosal fluid levels of granulocyte-macrophage colony-stimulating factor and interleukin-5. Am J Respir Crit Care Med. 2000;162:1705–1708.
Sim TC, Reece LM, Hilsmeier KA, Grant JA, Alam R. Secretion of chemokines and other cytokines in allergen-induced nasal responses: inhibition by topical steroid treatment. Am J Respir Crit Care Med. 1995;152:927–933.
Weido AJ, Reece LM, Alam R, Cook CK, Sim TC. Intranasal fluticasone propionate inhibits recovery of chemokines and other cytokines in nasal secretions in allergen-induced rhinitis. Ann Allergy Asthma Immunol. 1996;77:407–415.
Masuyama K, Till SJ, Jacobson MR, Kamil A, Cameron L, Juliusson S, et al.. Nasal eosinophilia and IL-5 mRNA expression in seasonal allergic rhinitis induced by natural allergen exposure: Effect of topical corticosteroids. J Allergy Clin Immunol. 1998;102 (4 II): 610–617.
Rak S, Jacobson MR, Sudderick RM, Masuyama K, Juliusson S, Kay AB, et al.. Influence of prolonged treatment with topical corticosteroid (fluticasone propionate) on early and late phase nasal responses and cellular infiltration in the nasal mucosa after allergen challenge. Clin Exp Allergy. 1994;24:930–939.
Lozewicz S, Wang J, Duddle J, Thomas K, Chalstrey S, Reilly G, et al.. Topical glucocorticoids inhibit activation by allergen in the upper respiratory tract. J Allergy Clin Immunol. 1992;89:951–957.
Author information
Authors and Affiliations
Corresponding author
Additional information
Conflicts of interest
There are no conflicts of interest.
Rights and permissions
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Mostafa, H.S., Fawzy, T.O., Ayad, E. et al. Effect of a prolonged topical glucocorticosteroid on interleukin-5 production and eosinophilic recruitment in the nasal submucosal compartment. Egypt J Otolaryngol 29, 151–155 (2013). https://doi.org/10.7123/01.EJO.0000426476.84637.e8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.7123/01.EJO.0000426476.84637.e8