- Case report
- Open access
- Published:
Post-tonsillectomy hemorrhage due to factor XIII deficiency
The Egyptian Journal of Otolaryngology volume 28, pages 278–280 (2012)
Abstract
Factor XIII deficiency is a very rare disorder, which represents a significant threat to life and can result in significant morbidity. Factor XIII is the final enzyme in the coagulation cascade and is essential for normal homeostasis. There is a very high rate of bleeding in patients who do not receive appropriate prophylaxis. We report a case of patient who presented with profuse secondary post-tonsillectomy hemorrhage few days after the operation.
References
Schroeder V, Meili E, Cung T, Schmutz P, Kohler HP. Characterisation of six novel A-subunit mutations leading to congenital factor XIII deficiency and molecular analysis of the first diagnosed patient with this rare bleeding disorder. Thromb Haemost. 2006; 95: 77–84
Laki K. Our ancient heritage in blood clotting and some of its consequences. Ann N Y Acad Sci. 1972; 202: 297–307
Folk JE, Finlayson JS. The epsilon-(gamma-glutamyl)lysine crosslink and the catalytic role of transglutaminases. Adv Protein Chem. 1977; 31: 1–133
Nugent DJ. Prophylaxis in rare coagulation disorders–factor XIII deficiency. Thromb Res. 2006;118(Suppl 1):S23–S28
Duckert F, Jung E, Shmerling DH. A hitherto undescribed congenital haemorrhagic diathesis probably due to fibrin stabilizing factor deficiency. Thromb Diath Haemorrh. 1960; 5: 179–186
Randall DA, Hoffer ME. Complications of tonsillectomy and adenoidectomy. OtolaryngolHead Neck Surg. 1998; 118: 61–68
Windfuhr JP, Chen YS, Remmert S. Hemorrhage following tonsillectomy and adenoidectomy in 15,218 patients. Otolaryngol Head Neck Surg. 2005; 132: 281–286
Rasmussen N. Complications of tonsillectomy and adenoidectomy. Otolaryngol Clin North Am. 1987; 20: 383–390
Alexander RJ, Kukreja R. Secondary post-tonsillectomy haemorrhage and informed consent. J Laryngol Otol. 2004; 118: 937–940
American Academy of Otolaryngology — Head and Neck Surgery. Tonsillectomy and adenoidectomy inpatient guidelines. Recommendations of the AAO-HNS Pediatric Otolaryngology Committee. St Louis, MO; 1996. pp. 1–4
Myssiorek D, Alvi A. Post-tonsillectomy hemorrhage: an assessment of risk factors. Int J Pediatr Otorhinolaryngol. 1996; 37: 35–43
Anwar R, Miloszewski KJ. Factor XIII deficiency. Br J Haematol. 1999; 107: 468–484
Tyler HM. A comparative study of the solvents commonly used to detect fibrin stabilisation. Thromb Diath Haemorrh. 1966; 16: 61–68
Reitsma PH. Genetic principles underlying disorders of procoagulant and anticoagulant proteins. In: Coleman RW, Hirsh J, Marder VJ et al., editors. Hemostasis and thrombosis: basic principles and clinical practice. Philadelphia, PA: Lippincott Williams & Wilkins; 2001. pp. 59–87.
Loewy AG, McDonagh J, Mikkola H. Structure and function of F XIII. In: Coleman RW, Hirsh J, Marder VJ, et al., editors. Hemostasis and thrombosis: basic principles and clinical practice. Philadelphia, PA: Lippincott Williams & Wilkins; 2001. pp. 233–248.
Lorand L, Losowsky MS, Miloszewski K. Human factor XIII: fibrin stabilizing factor. In: Spaet TH, editor. Progress in haemostasis and thrombosis. vol. 5 New York: NY7 Grune and Stratton Inc; 1980. pp. 245–289.
Author information
Authors and Affiliations
Corresponding author
Additional information
Conflicts of interest
There are no conflicts of interest.
Rights and permissions
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Albahkaly, S., Alkhunaizi, A. & Makki, F. Post-tonsillectomy hemorrhage due to factor XIII deficiency. Egypt J Otolaryngol 28, 278–280 (2012). https://doi.org/10.7123/01.EJO.0000418068.19559.fa
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.7123/01.EJO.0000418068.19559.fa