Skip to main content

Squamous cell carcinoma paradox in thyroid

Abstract

Squamous cell carcinoma (SCC) in the thyroid is extremely unusual, contributing to less than 1% of all primary thyroid carcinomas. It may be primary SCC of thyroid gland or secondary spread to the gland, owing to direct extension of SCC from neighboring structures or distant metastases. Most of the cases of thyroid malignancy present as a rapidly expanding mass in the neck, followed by symptoms of invasion and compression of nearby structures. This case report presents an atypical presentation of SCC in the thyroid gland. In this study, the patient presented with a huge thyroid swelling, with minimal dysphagia, mimicking a primary thyroid malignancy; unusually, the primary lesion in the esophagus was much smaller and found on endoscopic evaluation.

References

  1. Sapalidis K, Anastasiadis I, Panteli N, Strati TM, Liavas L, Poulios CKI. Primary squamous cell carcinoma of the thyroid. J Surg Case Rep 2014; 12:1–3.

    Google Scholar 

  2. Syed MI, Stewart M, Syed S, Dahill S, Adams C, McLellan DR, Clark LJ. Squamous cell carcinoma of the thyroid gland: primary or secondary disease? J Laryngol Otol 2011; 125:3–9.

    Article  CAS  Google Scholar 

  3. Struller F, Senne M, Falch C, Kirschniak A, Konigsrainer A, Muller S. Primary squamous cell carcinoma of the thyroid: case report and systematic review of the literature. Int J Surg Case Rep 2017; 37:36–40.

    Article  Google Scholar 

  4. Nakhjavani M, Gharib H, Goellner JR, Heerden JA. Direct extensions of malignant lesions to the thyroid gland from adjacent organs: report of 17 cases. Endocr Pract 1999; 5:69–71.

    Article  CAS  Google Scholar 

  5. Kim TJ, Kim HY, Lee KW, Kim MS. Multimodality assessment of esophageal cancer: preoperative staging and monitoring of response to therapy. Radiographics 2009; 29:403–421.

    Article  Google Scholar 

  6. Moghaddam PA, Cornejo KM. Metastatic carcinoma to the thyroid gland: a single institution 20-year experience and review of the literature. Endocr Pathol 2013; 24:116–124.

    Article  CAS  Google Scholar 

  7. Gwynne S, Wijnhoven BPL, Hulshof M, Bateman A. Role of chemoradiotherapy in oesophageal cancer adjuvant and neoadjuvant therapy statement of search strategies used and sources of information. Clin Oncol (R Coll Radiol) 2014; 26:522–532.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Meera Niranjan Khadilkar MS, DNB.

Additional information

This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.

Rights and permissions

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Dosemane, D., Khadilkar, M.N. & Dadul, R.C. Squamous cell carcinoma paradox in thyroid. Egypt J Otolaryngol 35, 361–363 (2019). https://doi.org/10.4103/ejo.ejo_67_18

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.4103/ejo.ejo_67_18

Keywords