Skip to main content
  • Original article
  • Open access
  • Published:

Vitamin D levels in children diagnosed with acute otitis media

Abstract

Objective

To investigate the relationship between acute otitis media (AOM) and vitamin D level in children.

Patients and methods

This prospective study was conducted at Assiut University Hospital between December 2016 and March 2017. The study group comprised ambulatory children who were diagnosed with AOM and healthy controls. The blood sample (5 cm) was taken immediately after the diagnosis of AOM in the laboratory for measuring serum 25-hydroxyvitamin D. Abnormal value=deficiency+insufficiency.

Results

Of the 40 children included in this study, 30 were the cases and 10 were controls. The mean age of the cases was 4.92±3.08 and 5.92±4.04 years for the controls besides 18 (60%) of the AOM group were boys and 12 (40%) were girls, compared with five (50%) boys and five (50%) were girls in the control group. Otalgia and congested tympanic membrane were present in all children of the diseased group. Also 70% had upper respiratory tract infection preceding the attack of AOM and 33.3% had previous attack of AOM. Twenty-two (73.3%) out of 30 children of the AOM group have an abnormal value of vitamin D and it was statistically significant than the control group.

Conclusion

Both vitamin D deficiency and insufficiency were significant in children suffering from AOM than normal children.

References

  1. Lee HJ, Park SK, Choi KY, Park SE, Chun YM, Kim KS, et al. Korean clinical practice guidelines: otitis media in children. J Korean Med Sci 2012; 27:835–848.

    Article  CAS  Google Scholar 

  2. Bikle D. Non classic actions of vitamin D. J Clin Endocrinol Metab 2009; 94:26–34.

    Article  CAS  Google Scholar 

  3. Ozkan B. Nutritional rickets. J Clin Res Pediatr Endocrinol 2010; 2:137–143.

    Article  Google Scholar 

  4. Hewison M. An update on vitamin D and human immunity. Clin Endocrinol (Oxf) 2012; 76:315–325.

    Article  CAS  Google Scholar 

  5. Edfeldt K, Liu PT, Chun R, Fabri M, Schenk M, Wheelwright M, et al. T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism. Proc Natl Acad Sci USA 2010; 107:22593–22598.

    Article  CAS  Google Scholar 

  6. Holick MF. Vitamin D: extraskeletal health. Endocrinol Metab Clin North Am 2010; 39:381–400.

    Article  CAS  Google Scholar 

  7. Huges DA, Norton R. Vitamin D and respiratory health. Clin Exp Immunol 2009; 158:20–25.

    Article  Google Scholar 

  8. Jartti T, Camarago C. Low serum 25-hydroxyvitamin D levels are associated with increased risk of viral coinfections in wheezing children. J Allergy Clin Immunol 2010; 126:1064–1066.

    Article  Google Scholar 

  9. Chonmaitree T, Revai K, Grady JJ, Clos A, Patel JA, Nair S, et al. Viral upper respiratory tract infection and otitis media complication in young children. Clin Infect Dis 2008; 46:815–823.

    Article  Google Scholar 

  10. Kalu SU, Ataya RS, McCormick DP, Patel JA, Revai K, Chonmaitree T. Clinical spectrum of acute otitis media complicating upper respiratory tract viral infection. Pediatr Infect Dis J 2011; 30:95–99.

    Article  Google Scholar 

  11. Bergman P. Can vitamin D supplementation prevent chronic otitis media with effusion? Acta Paediatr 2017; 106:1385–1386.

    Article  Google Scholar 

  12. Hewison M. Antibacterial effects of vitamin D. Nat Rev Endocrinol 2011; 7:337–345.

    Article  CAS  Google Scholar 

  13. Ashhurst-Smith C, Hall ST, Burns CJ, Stuart J, Blackwell CC. In vitro inflammatory responses elicited by isolates of Alloiococcus otitidis obtained from children with otitis media with effusion. Innate Immun 2014; 20:320–326.

    Article  Google Scholar 

  14. Marchisio P, Consonni D, Baggi E, Zampiero A, Bianchini S, Terranova L, et al. Vitamin D supplementation reduces the risk of acute otitis media in otitisprone children. Pediatr Infect Dis J 2013; 32:1055–1060.

    Article  Google Scholar 

  15. Cayir A, Turan MI, Ozkan O, Cayir Y. Vitamin D levels in children diagnosed with acute otitis media. J Pak Med Assoc 2014; 64:1274–1277.

    PubMed  Google Scholar 

  16. Li HB, Tai XH, Sang YH, Jia JP, Xu ZM, Cui XF, Dai S. Association between vitamin D and development of OM: A PRISMA-compliant meta-analysis and systematic review. Medicine 2016; 95:40.

    Article  Google Scholar 

  17. Sabetta JR, DePetrillo P, Cipriani RJ, Smardin J, Burns LA, Landry ML. Serum 25-hydroxyvitamin D and the incidence of acute viral respiratory tract infections in healthy adults. PLoS One 2010; 5:11088.

    Article  Google Scholar 

  18. Asghari A, Bagheri Z, Jalessi M, Salem MM, Amini E, GhalehBaghi S, Bakhti S. Vitamin D levels in children with adenotonsillar hypertrophy and otitis media with effusion. Iran J Otorhinolaryngol 2017; 29:29–33.

    PubMed  PubMed Central  Google Scholar 

  19. Hosseini S, Khajavi M, Eftekharian A, Akbari N. Vitamin D levels in children with otitis media with effusion: a case–control study. Thrita 2016; 5:e31977.

    Article  Google Scholar 

  20. Akcan FA, Dündar Y, Akcan HB, Uluat A, Cebeci D, Sungur MA, et al. Clinical role of vitamin D in prognosis of otitis media with effusion. Int J Pediatr Otorhinolaryngol 2018; 105:1–5.

    Article  Google Scholar 

  21. Walker RE, Bartley J, Camargo CA, Flint D, Thompson JMD, Mitchell EA. Higher serum 25(OH)D concentration is associated with lower risk of chronic otitis media with effusion: a case-control study. Acta Paediatr 2017; 106:1487–1492.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mohamed O. A. Gad MD.

Additional information

This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.

Rights and permissions

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Salem, M.A.M., Abdullah, M.M., Mohamed, Z.A. et al. Vitamin D levels in children diagnosed with acute otitis media. Egypt J Otolaryngol 35, 162–167 (2019). https://doi.org/10.4103/ejo.ejo_59_18

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.4103/ejo.ejo_59_18

Keywords