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The Egyptian Journal of Otolaryngology
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Helicobacter pylori in benign versus malignant laryngeal lesions

The Egyptian Journal of Otolaryngology volume 35, pages 47–50 (2019)Cite this article

Abstract

Objective

The aim was to investigate the existence of immunoglobulin (Ig)G antibody against Helicobacter pylori (H. pylori) in blood sample from patients having laryngeal lesions and comparing its level in benign versus malignant lesions.

Patients and Methods

Under general anesthesia, direct laryngoscopy was performed for patients having laryngeal lesions, and biopsy was taken and sent for histopathology. Anti-H. pylori IgG antibodies were measured by enzyme-linked immunosorbent assay from venous blood samples from each patient.

Results

Within the included 56 patients, 30 had benign lesion and 26 (46%) had squamous cell carcinoma (SCC). Overall, 73.3% of patient with benign lesions were seropositive and 92.3% of patient with laryngeal SCC were seropositive. The mean anti-H. pylori IgG antibody level was significantly (P=0.0041) higher in patients who had SCC (23.93±19.6) than patients who had benign laryngeal lesions (38.9±27.5).

Conclusion

Laryngeal lesions are commonly associated with H. Pylori infection and showed significantly higher level in laryngeal SCC than benign lesions, reflecting more association of larynx cancer with H. pylori infection.

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Authors and Affiliations

  1. Department of Otorhinolaryngology-Head and Neck Surgery, Zagazig University, Egypt

    Mohammad W. El-Anwar

  2. Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Zagazig University, Zagazig, 12411, Egypt

    Mohammad Abdehady MD

  3. Department of Department of Otorhinolaryngology, Alahrar Teaching Hospital, Zagazig, Egypt

    Ashraf Raafat

  4. Department of Department of Clinical Pathology, Benha Teaching Hospital, Benha, Egypt

    Eman A. Eissa

Authors
  1. Mohammad W. El-Anwar
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  2. Ashraf Raafat
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  3. Mohammad Abdehady MD
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  4. Eman A. Eissa
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Correspondence to Mohammad Abdehady MD.

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El-Anwar, M.W., Raafat, A., Abdehady, M. et al. Helicobacter pylori in benign versus malignant laryngeal lesions. Egypt J Otolaryngol 35, 47–50 (2019). https://doi.org/10.4103/ejo.ejo_28_18

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  • DOI: https://doi.org/10.4103/ejo.ejo_28_18

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