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Kimura’s disease of the tongue: a new case report


Kimura’s disease (KD), a chronic inflammatory disease of uncertain etiology, manifests as a painless subcutaneous swelling mostly in the head and neck region that involves major salivary glands and regional lymph nodes. To date, the majority of cases of KD have been documented in Asian men aged 20–40 years. However, the number of reported cases of KD involving the oral and maxillofacial area is limited, and since the masses appear similar to cysts or benign tumors, the establishment of an accurate preoperative diagnosis is challenging. The accurate diagnosis of KD is considered to require surgical excision followed by histopathological examination. In this case report, we present a case of KD affecting the ventral surface of the tongue, a unique site of the disease that is not reported earlier according to our knowledge.


  1. 1

    Kimura T, Yoshimura S, Ishikawa E. On the unusual granulation combined with hyperplastic changes of lymphatic tissues. Trans Soc Pathol Jpn 1948; 37:179–180.

    Google Scholar 

  2. 2

    Jani A, Coulson M. Kimura’s disease: a typical case of a rare disorder. West J Med 1997; 166:142–144.

    CAS  PubMed  PubMed Central  Google Scholar 

  3. 3

    Iida S, Fukuda Y, Ueda T, Sakai T, Okura M, Kogo M. Kimura’s disease: report of a case with presentation in the cheek and upper eyelid. J Oral Maxillofac Surg 2005; 63:690–693.

    Article  Google Scholar 

  4. 4

    Terakado N, Sasaki A, Takebayashi T, Matsumura T, Kojou T. A case of Kimura’s disease of the hard palate. Int J Oral Maxillofac Surg 2002; 31:222–224.

    CAS  Article  Google Scholar 

  5. 5

    Hongcharu W, Baldassano M, Taylor CR. Kimura’s disease with oral ulcers: response to pentoxifylline. J Am Acad Dermatol 2000; 43:905–907.

    CAS  Article  Google Scholar 

  6. 6

    Hobeika C, Mohammed T, Johnson G, Hansen K. Kimura’s disease: case report and review of the literature. J Thorac Imaging 2005; 20:298–300.

    Article  Google Scholar 

  7. 7

    Atar S, Oberman AS, Ben-Izhak O, Flatau E. Recurrent nephrotic syndrome associated with Kimura’s disease in a young non-Oriental male. Nephron 1994; 68:259–261.

    CAS  Article  Google Scholar 

  8. 8

    Tseng C, Lin H, Huang S. Kimura’s disease presenting as bilateral parotid masses. Eur Arch Otorhinolaryngol 2005; 262:8–10.

    Article  Google Scholar 

  9. 9

    Kung IT, Gibson JB, Bannatyne PM. Kimura’s disease: a clinico-pathological study of 21 cases and its distinction from angiolymphoid hyperplasia with eosinophilia. Pathology 1984; 16:39–44.

    CAS  Article  Google Scholar 

  10. 10

    Zhang R, Ban XH, Mo YX, Lv MM, Duan XH, Shen J, et al. Kimura’s disease: the CT and MRI characteristics in fifteen cases. Eur J Radiol 2011; 80:489–497.

    Article  Google Scholar 

  11. 11

    Mitsui M, Ogino S, Ochi K, Ohashi T. Three cases of eosinophilic lymphfolliculoid granuloma of the soft tissue originating from the parotid gland. Acta Otolaryngol Suppl 1996; 522:130–132.

    CAS  PubMed  Google Scholar 

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Correspondence to Dr. Belal Alani.

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Aldoori, M., Alani, B., Ammar, A. et al. Kimura’s disease of the tongue: a new case report. Egypt J Otolaryngol 34, 341–344 (2018).

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  • angiolymphoid hyperplasia
  • kimura
  • rare tongue lesion