- Case report
- Open Access
Isolated laryngeal amyloidosis: a case report
The Egyptian Journal of Otolaryngology volume 34, pages359–362(2018)
Amyloidosis is extracellular deposition of an amorphous amyloid substance in various tissues. It can occur in any bodily organ. Clinically, it is divided into systemic and solitary amyloidosis. Isolated laryngeal amyloidosis is very rare in prevalence. We report a case of isolated laryngeal amyloidosis in a healthy 54-year-old lady who presented chronic dysphonia for 2 years with no history of smoking or alcohol intake. The histological, immunohistochemical study and further examinations confirmed the diagnosis of isolated laryngeal amyloidosis without systemic involvement. The larynx is a rare site for isolated laryngeal amyloidosis. Hoarseness or dysphonia is the main presentation of this disease, followed by difficulty in breathing, stridor, and chronic cough. Laryngoscopy may falsely suggest a neoplastic disease. Histopathology is the gold standard diagnostic tool to diagnose this disease. Amyloid can be identified histologically as subepithelial extracellular deposits of acellular, homogeneous, and amorphous eosinophilic material displaying apple–green birefringence with polarized light when stained with Congo red. Surgery is the mainstay of treatment of symptomatic laryngeal amyloidosis. The survival of patients with laryngeal amyloidosis often exceeds 10 years and the prognosis is better than systemic amyloidosis.
Pribtikin E, Friedman O, OHara B, Cunnane MF, Levi D, Rosen M, et al. Amyloidosis of the upper aerodigestive tract. Laryngoscope 2003; 113:2095–2101.
Michaels L, Hyams VJ. Amyloid in localized deposits and plasmocytomas of the respiratory tract. J Pathol 1979; 128:29–38.
Raymond AK, Sneige N, Batsakis JG. Pathology consultation. Amyloidosis in the upper aerodigestive tracts. Ann Otol Rhinol Laryngol 1992; 101:794–796.
Motta G, Salzano FA, Motta S, Staibano S. CO2-laser treatment of laryngeal amyloidosis. J Laryngol Otol 2003; 117:647–650.
Benning S, Technau-Ihling K, Fisch P, Fradis M, Schipper J, Maier W. Amyloid tumor of the larynx associated with plasma cell infiltration: differential diagnosis. Ear Nose Throat J 2004; 83:839–843.
Alaani A, Warfield AT, Path FRC, Pracy JP. Management of laryngeal amyloidosis. J Laryngol Otol 2004; 118:279–283.
Berg AM, Troxler RF, Grillone G, Kasznica J, Cohen AS, Skinner M. Localized amyloidosis of the larynx: evidence for light chain composition. Ann Otol Rhinol Laryngol 1993; 102:884–889.
Daudia A, Motamed M, Lo S. Primary amyloidosis of the larynx. Postgrad Med J 2000; 76:364–365.
Avitia S, Hamilton JS, Osborne RF. Surgical rehabilitation for primary laryngeal amyloidosis. Ear Nose Throat J 2007; 86:206–208. ?
Feingold RM. Laryngeal amyloidosis. J Insur Med 2012; 43:32–35.
This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
About this article
Cite this article
Zainol, S., Azman, M. & Muthusamy, S. Isolated laryngeal amyloidosis: a case report. Egypt J Otolaryngol 34, 359–362 (2018). https://doi.org/10.4103/ejo.ejo_12_18
- Congo red
- laryngeal neoplasms