Skip to main content
The Egyptian Journal of Otolaryngology
Download PDF
  • Original article
  • Open access
  • Published:

Selenium supplement for treatment of geriatric rhinitis

The Egyptian Journal of Otolaryngology volume 35, pages 135–139 (2019)Cite this article

Abstract

With the aging of population, the incidence of geriatric problems is increasing. However, the diagnosis and treatment of geriatric problems are usually ignored. This study investigated the efficacy of supplemental selenium in patients with geriatric rhinitis (GR). The study was conducted at an academic secondary referral center in a prospective design. Patients were divided into two groups, and they were compared with healthy volunteers. The treatment group, including patients with GR, was given nasal saline wash four times daily and 100 μg of seleno-6 dietary supplements twice daily. The patient control group and the healthy volunteers were given only the nasal saline wash four times daily. Glutathione peroxidase, superoxide dismutase, and catalase levels were measured in all participants before and after treatment. In addition, the sino-nasal outcome test-20 and visual analog scale were applied before and after treatment. In the selenium supplement group, the visual analog scale, sino-nasal outcome test-20 scores, and enzyme levels were significantly improved compared with the untreated group. No adverse effects occurred in the selenium supplement group during the study. Supplemental selenium might be effective in the treatment of GR in terms of aging physiology and the oxidative system. However, large-scale randomized studies are needed to determine the optimal treatment.

References

  1. Hazzard WR, Woolard N, Regenstreif DI. Internal medicine: at the nexus of the health care system in responding to the demographic imperative of an aging population. Am J Med. 2001; 110:507–513.

    Article  CAS  Google Scholar 

  2. Sahin-Yilmaz AA, Corey JP. Rhinitis in the elderly. Clin Allergy Immunol 2007; 19:209–219.

    PubMed  Google Scholar 

  3. Wilson W. Nose and throat disorders. In Beers MH, Berkow R, Bogin RM, Fletcher AJ, Rahman MI, eds. The Merck manual of geriatrics. 3rd ed. New Jersey: Merck Research Laboratories; 2000. 1344–1347

    Google Scholar 

  4. Sibbold B. Epidemiology of allergy rhinitis. Burr ML, Michael L, eds. Epidemiology of clinical allergy. Monographs in allergy. Basel: Karger; 1993. 61–79

    Google Scholar 

  5. Dumont E, Vanhaecke F,Cornelis R. Selenium speciation from food source to metabolites: a critical review. Anal Bioanal Chem 2006; 385:1304–1323.

    Article  CAS  Google Scholar 

  6. Stoffaneller R, Morse NL. A review of dietary selenium intake and selenium status in Europe and the Middle East. Nutrients 2015; 7:1494–1537.

    Article  CAS  Google Scholar 

  7. Mabry RL. Nasal stuffiness due to systemic medications. Otolaryngol Neck Surg 1983; 91:93–94.

    Article  CAS  Google Scholar 

  8. Browne JP, Hopkins C, Slack R, Cano SJ. The sino-nasal outcome test (SNOT): can we make it more clinically meaningful? Otolaryngol Neck Surg 2007; 136:736–741.

    Article  Google Scholar 

  9. Sunde R. Selenium. In Burk RF, Levander OA, eds. Modern nutrition in health and disease. Philadelphia, PA: Wolters Kluwer Health/Lippincott Williams & Wilkins; 1999. 265–276

    Google Scholar 

  10. Sanmartín C, Plano D, Sharma AK, Palop JA. Selenium compounds, apoptosis and other types of cell death: an overview for cancer therapy. Int J Mol Sci 2012; 13:9649–9672.

    Article  Google Scholar 

  11. Gao S, Jin Y, Unverzagt FW, Liang C, Hall KS, Cao J, et al. Selenium level and depressive symptoms in a rural elderly Chinese cohort. BMC Psychiatry 2012; 12:72.

    Article  Google Scholar 

  12. Ray AL, Semba RD, Walston J, Ferrucci L, Cappola AR, Ricks MO, et al. Low serum selenium and total carotenoids predict mortality among older women living in the community: the women’s health and aging studies. J Nutr 2006; 136:172–176.

    Article  CAS  Google Scholar 

  13. Semba RD, Ricks MO, Ferrucci L, Xue Q-L. , Guralnik JM, Fried LP. Low serum selenium is associated with anemia among older adults in the United States. Eur J Clin Nutr 2009; 63:93–99.

    CAS  PubMed  Google Scholar 

  14. Prinzinger R. Programmed ageing: the theory of maximal metabolic scope. How does the biological clock tick? EMBO Rep 2005; 6:S14–S19.

    Article  CAS  Google Scholar 

  15. Jordan JA, Mabry RL. Geriatric rhinitis: what it is, and how to treat it. Geriatrics 1998; 53:76.

    CAS  PubMed  Google Scholar 

  16. Gebre-Medhin M, Ewald U, Plantin LO, Tuvemo T. Elevated serum selenium in diabetic children. Acta Paediatr Scand 1984; 73:109–114.

    Article  CAS  Google Scholar 

  17. Yang GQ, Xia YM. Studies on human dietary requirements and safe range of dietary intakes of selenium in China and their application in the prevention of related endemic diseases. Biomed Environ Sci 1995; 8:187–201.

    CAS  PubMed  Google Scholar 

  18. Sun H-J, Rathinasabapathi B, Wu B, Luo J, Pu L-P, Ma LQ. Arsenic and selenium toxicity and their interactive effects in humans. Environ Int 2014; 69:148–158.

    Article  CAS  Google Scholar 

  19. Zeyrek D, Soran M, Cakmak A, Kocyigit A, Iscan A. Serum copper and zinc levels in mothers and cord blood of their newborn infants with neural tube defects: a case-control study. Indian Pediatr 2009; 46:675–680.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Otolaryngology Department Koru Hospitals, Otorhinolaryngology Clinic, Ankara, Turkey

    Esin Yalcinkaya MD

  2. Otolaryngology Department, Mardin State Hospital, Ministry of Health, Otorhinolaryngology Clinic, Mardin, Turkey

    Hasmet Yazici & Fatih K. Soy

  3. Department of Pharmacology, Yuksek Ihtisas University, Ankara, Turkey

    Hakan Kayir

  4. Department of Otorhinolaryngology, Faculty of Medicine, Cairo University, Cairo, Egypt

    Hesham Negm

Authors
  1. Esin Yalcinkaya MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hasmet Yazici
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hakan Kayir
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Fatih K. Soy
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hesham Negm
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Esin Yalcinkaya MD.

Additional information

This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.

Rights and permissions

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yalcinkaya, E., Yazici, H., Kayir, H. et al. Selenium supplement for treatment of geriatric rhinitis. Egypt J Otolaryngol 35, 135–139 (2019). https://doi.org/10.4103/ejo.ejo_102_18

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.4103/ejo.ejo_102_18

Keywords