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Intermediate-grade mucoepidermoid carcinoma arising from Warthin’s tumour of parotid gland


Warthin’s tumour (WT), also known as the adenolymphoma, is the second common benign neoplasm that mostly occurs in the parotid gland. Malignant transformation of the epithelial or lymphoid component of the WT has been rarely reported. We describe a case of a 73-year-old woman who underwent total radical parotidectomy with modified neck dissection on the left side. The case was diagnosed as intermediate-grade mucoepidermoid carcinoma developed in the setting of WT based on histomorphologic findings. Clinical presentation, pathogenesis, differential diagnosis and management of the rare malignancy have been discussed briefly.


  1. 1

    Huvos AG, Paulino AFG. In: Stenberg SS, ed. Salivary glands. Diagnostic surgical pathology. 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 1999. 861–862.

    Google Scholar 

  2. 2

    Gunduz M, Yamanaka N, Hotomi M, et al. Squamous cell carcinoma arising in a Warthin’s tumor. Auris Nasus Larynx 1999; 26: 355–360.

    CAS  Article  Google Scholar 

  3. 3

    Skalova A, Michal M, Nathansky Z. Epidermoid carcinoma arising in Warthin’s tumour: a case study. J Oral Pathol Med 1994; 23: 330–333.

    CAS  Article  Google Scholar 

  4. 4

    Morrison GAJ, Shaw HJ. Squamous carcinoma arising within a Warthin’s tumor of the parotid gland. J Laryngol Otol 1988; 102: 1189–1191.

    CAS  Article  Google Scholar 

  5. 5

    Damjanov I, Sneff EM, Delerme AN. Squamous cell carcinoma arising in Warthin’s tumor of the parotid gland. A light, electron microscopic, and immunohistochemical study. Oral Surg Oral Med Oral Pathol 1982; 55: 286–290.

    Article  Google Scholar 

  6. 6

    Bengoechea O, Sanchez F, Larrinaga B, Martinez-Penuela JM. Oncocytic adenocarcinoma arising in Warthin’s tumor. Pathol Res Pract 1989; 185: 907–911.

    CAS  Article  Google Scholar 

  7. 7

    Therkildsen MH, Christensen N, Andersen LJ, Larsen S, Katholm M. Malignant Warthin’s tumour: a case study. Histopathology 1992; 21: 167–171.

    CAS  Article  Google Scholar 

  8. 8

    Bell D, Luna MA. Warthin adenocarcinoma: analysis of 2 cases of a distinct salivary neoplasm. Ann Diagn Pathol 2009; 13: 201–207.

    Article  Google Scholar 

  9. 9

    Deodhar KK, Shah M, Chaturvedi P. High-grade adenocarcinoma (ductal type) arising in unilateral Warthin tumour of the parotid gland. Indian J Pathol Micrbiol 2011; 54: 574–577.

    Article  Google Scholar 

  10. 10

    Nagao T, Sugano I, Ishida Y, Tajima Y, Furuya N, Kondo Y, et al. Mucoepidermoid carcinoma arising in Warthin’s tumour of the parotid gland: report of two cases with histopathological, ultrastructural and immunohistochemical studies. Histopathology 1998; 33: 379–386.

    CAS  Article  Google Scholar 

  11. 11

    Yamada S, Matsuo T, Fujita S, Suyama K, Yamaguchi A, Mizuno A. Mucoepidermoid carcinoma arising in Warthin’s tumor of parotid gland. Pathology Int 2002; 52: 653–656.

    Article  Google Scholar 

  12. 12

    Mardi K, Sharma J. Mucoepidermoid carcinoma arising in Warthin’s tumor: a case report. Indian J Pathol Microbial 2007; 50: 331–333.

    Google Scholar 

  13. 13

    Mohapatra M, Satyanarayana S. Low grade mucoepidermoid carcinoma in a setting of Warthin’s tumor. Indian J Pathol Microbiol 2012; 55: 392–394.

    Article  Google Scholar 

  14. 14

    Ferrero S, Cattaneo L, Peri A, Braidotti P, Cioffi U, Scaramallini G, et al. Poorly differentiated carcinoma arising from adenolymphoma of the parotid gland. BMC Surg 2003; 3: 1.

    Article  Google Scholar 

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Correspondence to Arsheed H. Hakeem MBBS, MS.

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Hakeem, A.H., Hakeem, I.H. & Wani, F.J. Intermediate-grade mucoepidermoid carcinoma arising from Warthin’s tumour of parotid gland. Egypt J Otolaryngol 32, 113–115 (2016).

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  • intermediate-grade mucoepidermoid carcinoma
  • parotid gland
  • Warthin’s tumour