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Role of PET-CT scan in synchronous primary cancers of the upper aerodigestive tract: a case report
The Egyptian Journal of Otolaryngology volume 32, pages 75–78 (2016)
Abstract
Oral field cancerization though not a new concept, has time and again, proven to be a challenge to the clinician, in terms of diagnosis and management. Prolonged exposure of the aerodigestive tract to carcinogens causes multifocal cancers. Intraepithelial migration of dysplastic or clonal cells becomes the seed for different primaries in the same field. The probability of synchronous malignancies should be borne in mind while evaluating a patient with head and neck cancer. With the advent of highly specific diagnostic tools like the PET scan, the chances of missing a second primary are eliminated/negligible. This is a case report on a patient who was found to have multiple primaries on clinical and radiological evaluation. Patient underwent multimodality treatment with chemoradiotherapy followed by surgery and is currently under follow-up. We aim to highlight the role of PET scanning in the evaluation of head and neck cancer to prevent missing a second primary.
References
DeVries N. The magnitude of the problem. In: De Vries N and Gluckman JL (Eds). Multiple primary tumours in the head and neck. Stuttgart, Germany: Georg Thieme Verlag; 1990. 1–29.
Krishnatreya M, Rahman T, Kataki AC, Das A, Das AK, Lahkar K. Synchronous primary cancers of the head and neck region and upper aero digestive tract: defining high-risk patients. Indian J Cancer 2013; 50: 322–326.
Sapkota A, Gajalakshmi V, Jetly DH, Roychowdhury S, Dikshit RP, Brennan P, et al. Smokeless tobacco and increased risk of hypopharyngeal and laryngeal cancers: a multicentric case-control study from India. Int J Cancer 2007; 121: 1793–1798.
Castaldi P, Leccisotti L, Bussu F, Micciche F, Rufini V. Role of (18)F-FDG PET-CT in head and neck squamous cell carcinoma. Acta Otorhinolaryngol Ital 2013; 33: 1–8.
Slaughter DP, Southwick HW, Smejkal W. Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin. Cancer 1953; 6: 963–968.
Sun L, Wan Y, Lin Q, Sun YH, Zhao L, Luo ZM, Wu H. Multiple primary malignant tumors of upper gastrointestinal tract: a novel role of 18 F-FDG PET/CT. World J Gastroenterol 2010; 16: 3964–3969.
Mukundan H, Sarin A, Gill BS, Neelakantan A. MRI and PET-CT: comparison in post-treatment evaluation of head and neck squamous cell carcinomas. Med J Armed Forces India 2014; 70: 111–115.
Huang SH, Chien CY, Lin WC, Fang FM, Wang PW, Lui CC, et al. A comparative study of fused FDG PET/MRI, PET/CT, MRI, and CT imaging for assessing surrounding tissue invasion of advanced buccal squamous cell carcinoma. Clin Nucl Med 2011; 36: 518–525.
Van Oijen MG, Leppers Vd Straat FG, Tilanus MG, Slootweg PJ. The origins of multiple squamous cell carcinomas in the aerodigestive tract. Cancer 2000; 88: 884–893.
Warren S, Gates O. Multiple primary malignant tumors: a survey of the literature and statistical study. Am J Cancer 1932; 16: 1358–1414.
Braakhuis BJ, Tabor MP, Leemans CR, van der Waal I, Snow GB, Brakenhoff RH. Second primary tumors and field cancerization in oral and oropharyngeal cancer: molecular techniques provide new insights and definitions. Head Neck 2002; 24: 198–206.
Hulikal N, Ray S, Thomas J, Fernandes DJ. Second primary malignant neoplasms: a clinicopathological analysis from a cancer centre in India. Asian Pac J Cancer Prev 2012; 13: 6087–6091.
Mehdi I. Synchronous and metachronous malignant tumors. J Clin Oncol 2010; 28: e19664.
Jayam R. Oral field cancerization: A review. J Indian Acad Oral Med Radiol 2010; 22: 201–205.
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Chandrasekharan, R., Ralte, Z., Paul, R.R. et al. Role of PET-CT scan in synchronous primary cancers of the upper aerodigestive tract: a case report. Egypt J Otolaryngol 32, 75–78 (2016). https://doi.org/10.4103/1012-5574.175864
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DOI: https://doi.org/10.4103/1012-5574.175864