- Original article
- Open access
- Published:
Auditory dysfunction in patients with type 2 diabetes mellitus with poor versus good glycemic control
The Egyptian Journal of Otolaryngology volume 31, pages 162–169 (2015)
En
Abstract
Background
Auditory functions among patients with type 2 diabetes mellitus (DM) are controversial regarding cochlear or neural changes and the relationship between these changes and serum level of glycosylated hemoglobin (HbA 1c%).
Aim of the study
The aim of the study was to investigate auditory dysfunctions in type 2 DM patients with poor versus good glycemic control.
Materials and methods
The present study was conducted on three groups: two diabetic groups with poor and good glycemic control (n = 18 and 14, respectively) based on serum HbA 1c% and one healthy control group (n = 30) matched with age, sex, and BMI. All participants were subjected to clinical assessment, audiometry, brainstem auditory evoked potential (BAEP), and evoked acoustic emissions transient evoked otoacoustic emissions and distortion product otoacoustic emissions (TEOAEs and DPOAEs).
Results
Diabetic patients with poor glycemic control had significantly elevated hearing thresholds compared with other groups at low and high frequencies in audiometry (P < 0.01 and P < 0.001). They showed significantly prolonged absolute latency in wave I and interpeak latency (III-V) in the BAEP test compared with other groups (P < 0.001). DM patients with poor glycemic control had significantly low amplitudes at all frequencies in the TEOAE test, as well as at high frequencies (4 and 6 kHz) on the DPOAE test, compared with other groups (P < 0.001 and P < 0.05, respectively). There were significant correlations between HbA 1c% and interpeak latency III-V (r = 0.340, P = 0.004) on the one hand and overall response of TEOAE amplitude (r = −0.471; P = 0.000) on the other.
Conclusion
Diabetic patients with poor glycemic control had worse auditory dysfunctions on both cochlear and neural findings.
References
Giniþ Z, Öztürk G, Sýrmalý R, Yalçýndað A, Dülgeroðlu Y, Delibaþý T, Delibaþ N. The role of HbA1c as a screening and diagnostic test for diabetes mellitus in Ankara. Turk J Med Sci 2012; 42: 1430–1436.
Wu HP, Guo YL, Cheng TJ, Hsu CJ. Chronological changes in compromised olivocochlear activity and the effect of insulin in diabetic Wistar rats. Hear Res 2010; 270: 173–178.
Austin DF, Konrad-Martin D, Griest S, McMillan GP, McDermott D, Fausti S. Diabetes-related changes in hearing. Laryngoscope 2009; 119: 1788–1796.
Fukui M, Kitagawa Y, Nakamura N, Kadono M, Mogami S, Ohnishi, M, et al. Idiopathic sudden hearing loss in patients with type 2 diabetes. Diabetes Res Clin Pract 2004; 63:205–211.
Diniz TH, Guida HL. Hearing loss in patients with diabetes mellitus. Braz J Otorhinolaryngol 2009; 75: 573–578.
Friedman SA, Schulman RH, Weiss S. Hearing and diabetic neuropathy. Arch Intern Med 1975; 135: 573–576.
Ferreira JM, Sampaio FMO, Rabbit JMS, Alemida NMGS. Audiological profile of patients with diabetes mellitus type II. Rev Soc Bras Fonoaudiol 2007; 12: 292–297.
Brender E, Burke AE, Glass RM. JAMA patient page. Audiometry. JAMA 2006; 295: 460.
Fernandes LC, Casais-Silva L, Ladeia AM. Dysfunction of the peripheral and central auditory pathway in patients with type 1 diabetes mellitus. J Diabetes Mellitus 2012; 2: 76–81.
Roeser RG, Buckley KA, Stickney GS. Pure tone tests. In: Roeser RG, Valente M, Hosford-Dunn H, (editors) Audiology, diagnosis. New York: Thieme Medical Publishers; 2000. 227–251.
Kemp DT, Ryan S, Bray P. A guide to the effective use of otoacuostic emission. Ear Hear 1990; 11: 93–105.
Sztuka A, pospiech L, Gawron W, Dudek K. DPOAEs in estimation of the function of the cochlea in tinnitus patients with normal hearing. Auris Nasus larynx 2010; 37: 55–60.
Gorga MP, Neely ST, Bergman B, Beauchaine KL, Kaminski JR, Peters J, Jesteadt W. Otoacoustic emission from normal hearing and hearing impaired subjects: distortion products responses. J Acoustic Soc Am 1993; 93: 2050–2060.
Karabulut H, Karabulut I, Daðli M, Bayazit YA, Bilen S, Aydin Y, et al. Evaluation of outer hair cell function and medial olivocochlear efferent system in patients with type II diabetes mellitus. Turk J Med Sci 2014; 44: 150–156.
Cullen JR, Cinnamond MJ. Hearing loss in diabetics. J Laryngol Otol 1993; 107: 179–182.
Tomkin GH. Malabsorption of vitamin B12 in diabetic patients treated with phenformin: a comparison with metformin. Br Med J 1973; 3: 673–675.
Makishima K, Tanaka K. Pathological changes of the inner ear and central auditory pathway in diabetics. Ann Otol Rhinol Laryngol 1971; 80: 218–228.
Bayazit Y, Yilmaz M, Kepekçi Y, Mumbuç S, Kanlikama M. Use of the auditory brainstem response testing in the clinical evaluation of the patients with diabetes mellitus. J Neurol Sci 2000; 181(1–2): 29–32.
Tóth F, Várkonyi TT, Rovó L, Lengyel C, Légrády P, Jóri J, et al. Investigation of auditory brainstem function in diabetic patients. Int Tinnitus J 2003; 9: 84–86.
Dolu H, Ulas UH, Bolu E, Ozkardes A, Odabasi Z, Ozata M, Vural O. Evaluation of central neuropathy in type II diabetes mellitus by multimodal evoked potentials. Acta Neurol Belg 2003; 103: 206–211.
Díaz de León-Morales LV, Jáuregui-Renaud K, Garay-Sevilla ME, Hernández-Prado J, Malacara-Hernández JM. Auditory impairment in patients with type 2 diabetes mellitus. Arch Med Res 2005; 36:507–510.
Talebi M, Moosavi M, Mohamadzade NA, Mogadam R. Study on brainstem auditory evoked potentials in diabetes mellitus. Neurosciences (Riayadh) 2008; 13: 370–373.
Huang CR, Lu CH, Chang HW, Tsai NW, Chang WN. Brainstem auditory evoked potentials study in patients with diabetes mellitus. Acta Neurol Taiwan 2010; 19: 33–40.
Orts Alborch M, Morant Ventura A, García Callejo J, Pérez del Valle B, Lorente R, Marco Algarra J. The study of otoacoustic emissions in diabetes mellitus. Acta Otorrinolaringol Esp 1998; 49:25–28.
Dabrowski M, Mielnik-Niedzielska G, Nowa-kowski A. Involvement of the auditory organ in type 1 diabetes mellitus. Endokrynol Pol 2011; 62: 138–144.
Ottaviani F, Dozio N, Neglia CB, Riccio S, Scavini M. Absence of otoacoustic emissions in insulin-dependent diabetic patients: is there evidence for diabetic cochleopathy? J Diabetes Complications 2002; 16: 338–343.
Ugur AK, Kemaloglu YK, Ugur MB, Gunduz B, Saridogan C, Yesilkaya E, et al. Otoacoustic emissions and effects of contralateral white noise stimulation on transient evoked otoacoustic emissions in diabetic children. Int J Pediatr Otorhinolaryngol 2009; 73: 555–559.
Lisowska G, Namyslowski G, Morawski, K, Strojek K. Cochlear dysfunction and diabetic microangiopathy. Scand Audiol 2001; 30: 199–203.
Fukushima H, Cureoglu S, Schachern PA, Kusunoki T, Oktay MF, Fukushima N, et al. Cochlear changes in patients with type 1 diabetes mellitus. Otolaryngol Head Neck Surg 2005; 133:100–106.
Erdem T, Ozturan O, Miman MC, Ozturk C, Karatas, E. Explorations of the early auditory effects of hyperlipoproteinemia and diabetes mellitus using otoacoustics emissions. Eur Arch Otorhinolaryngol 2003; 260: 62–66.
Durmus C, Vetiser S, Durmus O. Auditory brainstem evoked responses in insulindependent (ID) and non-insulin-dependent (NID) diabetic subjects with nor- mal hearing. Int J Audiol 2004; 43: 29–33.
Bittar RSM, Sanchez TG, Santoro PP, Medeiros IRT. The metabolism of glucose and the inner ear. Archives of Otolaryngology Foundation 1998; 2: 4–8.
Seidl R, Birnbacher R, Hauser E, Bernert G, Freilinger M, Schober E. Brainstem auditory evoked potentials and visually evoked potentials in young patients with IDDM. Diabetes Care 1996; 19: 1220–1224.
Author information
Authors and Affiliations
Corresponding author
Additional information
This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
Financial support and sponsorship
Nil.
Conflicts of interest
There are no conflicts of interest.
Rights and permissions
This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Abo-Elfetoh, N.M., Mohamed, E.S., Tag, L.M. et al. Auditory dysfunction in patients with type 2 diabetes mellitus with poor versus good glycemic control. Egypt J Otolaryngol 31, 162–169 (2015). https://doi.org/10.4103/1012-5574.161603
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.4103/1012-5574.161603