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Malignant laryngeal fibrous histiocytoma: a new concept of management


A 75-year-old male patient presented to the Speech and Language Disorder Outpatient Clinic of King Abdullah Medical City, Makkah, Saudi Arabia, on February, 2010, with a complaint of gradual onset and progressive course of dysphonia for 2 years. Nasofibrolaryngoscopic examination indicated a polipoidal mass of about 1.5 × 1 cm masking the entire glottic inlet. The mass was removed by direct laryngoscopy and diagnosed as a malignant fibrous histiocytoma. The patient developed recurrence of the tumor on the same site postoperatively and underwent the same procedure of excision, followed by a second recurrence. Direct laryngoscopic excision of the tumor was performed for a third time, but with a safety margin of 2 mm. Monthly follow-up examination indicated no postoperative recurrence till 10 months.


  1. 1

    Kauffman SL, Stout AP. Histiocytic tumors (fibromas, xanthoma and histiocytoma) in children. Cancer 1961; 14: 469–482.

    CAS  Article  Google Scholar 

  2. 2

    Cao X, Liu J, Zheng Y Li Q, Teng Y, Li Y. Simultaneous squamous cell carcinoma with primary malignant fibrous histiocytoma of the larynx: a case report. Mol Med Report 2012; 5: 971–973.

    CAS  Article  Google Scholar 

  3. 3

    Kuwabara H, Saito K, Shibanushi T, Kawahara T. Malignant fibrous histiocytoma of the larynx. Eur Arch Otorhinolaryngol 1994; 251: 178–182.

    CAS  Article  Google Scholar 

  4. 4

    Saleem M, MacArthur PD, Hainau B, Velagapudi SB. Pathology in focus: fibrous histiocytoma of the larynx. J Laryngol Otol 1998; 112: 1205–1207.

    CAS  Article  Google Scholar 

  5. 5

    Contreras LI, Macias RA, Díaz M, Castrolópez TV, Medina OC. Fibrohistiocitoma maligno de laringe. An Otorrinolaringol Ibero Am 1997; 24: 241–246.

    Google Scholar 

  6. 6

    Barnes L, Kanbour A. Malignant fibrous histiocytoma of the head and neck. Arch Otolaryngol Head Neck Surg 1988; 114: 1149–1156.

    CAS  Article  Google Scholar 

  7. 7

    Godoy J, Jacobs JR, Crissman J. Malignant fibrous histiocytoma of the larynx. J Surg Oncol 1986; 31: 62–65.

    CAS  Article  Google Scholar 

  8. 8

    Blitzer A, Lawson W, Biller HF. Malignant fibrous histiocytoma of the head and neck. Laryngoscope 1977; 87: 1479–1499.

    CAS  Article  Google Scholar 

  9. 9

    Bish OF, Clemente RJ, Ruiz GH, Fernández DEJ, Borge MF. Malignant laryngeal fibrous histiocytoma (MLFH). Report of two unusual cases. Acta Otorrinolaringol Esp 2004; 55: 390–394.

    Article  Google Scholar 

  10. 10

    Soh KB, Westmore GA, Moir AA, Colloby PS. Malignant fibrous histiocytomas of the larynx-report of two cases. Ann Acad Med Singapore 1996; 25: 878–881.

    CAS  PubMed  Google Scholar 

  11. 11

    Munjal M, Sood N, Shah BS, Malhotra V. Malignant fibrohistocytoma of the larynx. Indian J Otolaryngol Head Neck Surg 2004; 56: 289–290.

    PubMed  PubMed Central  Google Scholar 

  12. 12

    Sabesan T, Xuexi W, Yongfa Q, Pingzhang T, Ilankovan V. Malignant fibrous histiocytoma: outcome of tumours in the head and neck compared with those in the trunk and extremities. Br J Oral Maxillofac Surg 2006; 44: 209–212.

    CAS  Article  Google Scholar 

  13. 13

    Bilewicz R, Wierzchowska M, Burduk PK, Szukalski J. Malignant fibrohistiocytoma of the larynx [article in Polish]. Otolaryngol Pol 2007; 61: 325–328.

    CAS  Article  Google Scholar 

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Corresponding author

Correspondence to Mian U. Farooq MBBS, MBA, MSc.

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There are no conflicts of interest.

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Alherabi, A., Aboloyoun, A.I., Hamid, T. et al. Malignant laryngeal fibrous histiocytoma: a new concept of management. Egypt J Otolaryngol 31, 199–201 (2015).

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  • fibrous histiocytoma
  • laryngeal cancer
  • laryngoscopy
  • malignant