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The Egyptian Journal of Otolaryngology
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Preoperative gabapentin decreases the incidence of postoperative vomiting and analgesic requirements after pediatric adenotonsillectomy

The Egyptian Journal of Otolaryngology volume 30, pages 225–228 (2014)Cite this article

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Abstract

Objective

The aim of the study was to evaluate the effect of preoperative gabapentin on the incidence of postoperative vomiting (POV) and on analgesic requirements after adenotonsillectomy in pediatrics.

Patients and methods

A total of 144 pediatric patients (4-8 years) scheduled for elective adenotonsillectomy were randomly assigned to either the gabapentin (G) group (20 mg/kg, 2 h before surgery) or the placebo (P) group. A standard technique was used for anesthesia. Ondansetron (0.1 mg/kg) was used as a rescue antiemetic and ketorolac (1 mg/kg) was used as a rescue analgesic postoperatively. The prevalence of POV and number of patients who required ketorolac as a rescue analgesic were assessed in the first 6 h after surgery.

Results

Of the 72 patients, 15 patients (20.8%) in the G group and 21 patients (43%) in the P group developed POV; the difference was statistically significant (P = 0.007). The number of patients who required analgesics in the G group was 14 (19.4%) and in the P group was 35 (48.6%), and the difference was statistically significant (P = 0.0004).

Conclusion

Our data show that preoperative gabapentin reduces the incidence of POV and the analgesic requirements after pediatric adenotonsillectomy.

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Authors and Affiliations

  1. Department of Anesthesia, Faculty of Medicine, Ain Shams University, Cairo, Egypt

    Mahmoud H. Mohamed MD

  2. Department of ENT, Faculty of Medicine, Ain Shams University, Cairo, Egypt

    Hesham Al-Sersy

Authors
  1. Mahmoud H. Mohamed MD
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  2. Hesham Al-Sersy
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Correspondence to Mahmoud H. Mohamed MD.

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None declared.

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Mohamed, M.H., Al-Sersy, H. Preoperative gabapentin decreases the incidence of postoperative vomiting and analgesic requirements after pediatric adenotonsillectomy. Egypt J Otolaryngol 30, 225–228 (2014). https://doi.org/10.4103/1012-5574.138478

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  • DOI: https://doi.org/10.4103/1012-5574.138478

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