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Advanced laryngeal cancer with skin infiltration: Survival analysis

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Abstract

Objective

The objective of this study was to investigate T4 laryngeal cancer patients with skin infiltration regarding survival and different variables that may influence the survival.

Study design

This was a retrospective analytic study.

Materials and methods

This study included 14 patients suffering from laryngeal carcinoma, with tumor extending to involve the skin of the front of the neck. Total laryngectomy was performed for all patients together with excision of the overlying skin, and pectoralis major myocutaneous flap was used for reconstruction of the skin defect in all patients. Analysis of the preoperative, operative, postoperative, and follow-up patients’ data was performed. The 1-, 2-, 3-, and 5-year survival rates were estimated.

Results

The overall mean survival time for all patients was 51.1 ± 8.3 months. The mean survival time for patients with recurrent disease was 16.4 ± 3.5 months and for patients without recurrent disease was 70.7 ± 6 months. The 1-, 2-, 3-, and 5-year survival rates were 92.9, 71.4, 64.3, and 50%, respectively. The univariate analysis revealed that previous treatment before definitive surgery was the only variable that had a statistical influence on the overall 5-year survival rate (P = 0.046).

Conclusion

Extended laryngectomy with skin removal offers reasonable 5-year survival rate for T4 laryngeal cancer patients with skin invasion, and reconstruction of the neck skin defect with a pectoralis major myocutaneous flap is a reliable method of repair.

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Correspondence to Mohamed Mosleh MD.

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None declared.

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Mosleh, M., Fathy, H. Advanced laryngeal cancer with skin infiltration: Survival analysis. Egypt J Otolaryngol 30, 122–125 (2014). https://doi.org/10.4103/1012-5574.133213

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Keywords

  • Laryngeal cancer
  • skin infiltration
  • survival rate
  • pectoralis major myocutaneous flap