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The Egyptian Journal of Otolaryngology
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Effect of chitosan on bone restoration in nasal bone defect: An experimental study

The Egyptian Journal of Otolaryngology volume 30, pages 94–101 (2014)Cite this article

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Abstract

Objective

The aim of this work was to study the effect of chitosan in restoration of bone defect (an experimental study).

Materials and methods

The study included 54 male guinea pigs. Nasal bone defect was done. The experimental animals were divided into a control group (group A), calcium sulfate group (group B), and chitosan-coated calcium sulfate group (group C). Three-dimensional computed tomography and histological examination were carried out at intervals of 1, 2, and 3 months for measuring the change in the size of the bone defect and confirmation of bone formation, respectively.

Results

The decrease in the size of the bone defect was significant in group C than in groups A and B. Also, histological results showed formation of woven bone after 1 month in groups B and C and formation of lamellar bone in group C in the second month, whereas the lamellar bone was formed in group B in the third month.

Conclusion

Radiological and histological studies showed that the new bone formation on defected nasal bone was more in group C. These findings suggest that chitosan is very effective in early bone formation.

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Faculty of Medicine, Benha University, Benha, Egypt

    Mosaad Elsisy, Ashraf Elhamshary & Yasser M. Haroon MD

  2. Department of Physics, Faculty Sciences, Benha University, Benha, Egypt

    Samira Sallam

Authors
  1. Mosaad Elsisy
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  2. Ashraf Elhamshary
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  3. Yasser M. Haroon MD
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  4. Samira Sallam
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Corresponding author

Correspondence to Yasser M. Haroon MD.

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None declared.

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Elsisy, M., Elhamshary, A., Haroon, Y.M. et al. Effect of chitosan on bone restoration in nasal bone defect: An experimental study. Egypt J Otolaryngol 30, 94–101 (2014). https://doi.org/10.4103/1012-5574.133202

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  • DOI: https://doi.org/10.4103/1012-5574.133202

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