- Original Article
- Open Access
Management of patients with cancer of the larynx in Suez Canal University Teaching Hospital: 5 years’ experience
The Egyptian Journal of Otolaryngology volume 30, pages30–33(2014)
Suez Canal University Hospital, which is the only tertiary care facility in the Suez Canal and Sinai area, is estimated to service more than 5 million patients. Cancer of the larynx, which is the most common head and neck cancer, is also the most common tumor presented to the otolaryngology departments.
To evaluate the results of interventional protocols for patients with cancer of the larynx treated in Suez Canal University Hospital.
Patients and methods
This was a retrospective study carried out on 53 patients with cancer of the larynx reviewed from 1 January 2007 to 1 January 2012 according to demographic, clinical, radiological, operative, pathological data, and possible complications.
Fifty-three patients, mean age 58 years (71.1% were from urban areas), were studied. The main presenting symptom was hoarseness of voice (66%). Glottis carcinoma was the most common type of cancer found in 41.1% patients.
Stage IVa was the most common presenting stage in 39.6% of the patients. Emergent tracheostomy was performed for 39.6% of the patients.
According to the treatment protocol, single treatment modality was recommended for 38 (71.6%) patients: 17 (32%) patients were recommended total laryngectomy, followed by radiotherapy in 11 (20.7%) patients, chemotherapy was recommended for eight (15.1%) patients, concurrent chemoradiotherapy was offered to one (1.9%) patient, and partial laryngectomy with preservation of both arytenoids was offered to one (1.9%) patient. In addition, 15 (28.4%) patients were subjected to combined therapy: total laryngectomy combined with radiotherapy in nine (17%) patients and total laryngectomy with chemoradiotherapy in six (11.4%) patients.
Although the standards of management of laryngeal carcinoma in Suez Canal University hospital are almost in compliance with regional and international standards, we need to deal with the time delay between the diagnosis and definitive treatment to revise the items in the medical records and its registration.
Jemal A, Siegel R, Ward E. Cancer statistics, 2007. CA Cancer J Clin 2007; 57: 43–66.
Farrington W, Weighill J, Jones P. Total laryngectomy for cancer of the larynx. J Laryngol Otol 1986; 100: 53–58.
Marioni G, Marchese-Ragona R, Cartei GA. Current opinion in diagnosis and treatment of laryngeal carcinoma. Cancer Treat Rev 2006; 32: 504–515.
Boring C, Squires T, Tong T. Cancer statistics. Cancer 1994; 44: 7–26.
Wake M. The urban/rural divide in head and neck cancer the effect of atmospheric pollution. Clin Otolaryngol 1993; 18: 298–302.
William B, David E, Robert H. Malignant tumors of the larynx; anatomy and embryology [part 6, section 5, chapter 107 - paragrah 2]. Cummings otolaryngology - head and neck surgery. 5th ed. Washington University School of Medicine: Mosby; 2010; 2:1482
Armstrong W, Netterville J. Anatomy of the larynx, trachea, and bronchi. Otolaryngol Clin North Am 1995; 28: 685–699.
Frazer E. The development of the larynx. J Anat Physiol 1909; 44: 156.
Michael S, Erik S, Udo S, Lawrence MR, Edward DL, Markus V. Atlas of anatomy. Head and Neuroanatomy (THIEME Atlas of Anatomy) [Paperback], 1st Edition, 2010, p. 414.
Michael G, George G, Martin J. Anatomy of the larynx. Scott-Brown’s Otorhinolaryngology Head and Neck Surgery [chapter 162]. 7th ed. Michael J Gleeson, George Browning, Martin J Burton, Ray C Clarke, John Hibbert, Nicholas Jones, et al. (Editors): Hodder Arnold: London; 2008; 2:2132.
Janfaza P, Nadol J, Galla R. Surgical anatomy of the head and neck [chapter 11]. Anatomy of the neck. Philadelphia: lippincott Williams & Wilkins; 2001.
Van de Graff W. Thoracic influence on upper airway patency. J Appl Physiol 1988; 65:2124–2131
Sant’Ambrogio F, Mathew O, Clark W. Laryngeal influences on breathing pattern and posterior cricoarytenoid muscle activity. J Appl Physiol 1985; 58:1298–1304.
Brancatisano T, Dodd D, Engel L. Respiratory activity of the posterior cricoarytenoid muscle and vocal cords in humans. J Appl Physiol 1984; 57: 1143–1149.
Hagen P, Lyons G, Haindel C. Verrucous carcinoma of the larynx: role of human papilloma virus, radiation, and surgery. Laryngoscope 1993; 103: 253–257.
Ferlito A, Altavilla G, Rinaldo A. Basaloid squamous cell carcinoma of the larynx and hypopharynx. Ann Otol Rhinol Laryngol 1997; 106: 1024–1035.
Paulino A, Singh B, Shah J. Basaloid squamous cell carcinoma of the head and neck. Laryngoscope 2000; 110: 1479–1482.
Thompson L, Wieneke J, Miettinen M. Spindle cell (sarcomatoid) carcinomas of the larynx. Am J Surg Pathol 2002; 26: 153–170.
Cardesa A, Zidar N. Barnes L, Eveson JW, Reichart P, Sidransky D, (editors). Spindle cell carcinoma. World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. Lyon: IARC Press; 2005; 127–128.
Koch B, Trask D, Hoffman H. National survey of head and neck verrucous carcinoma: patterns of presentation, care, and outcome. Cancer 2001; 92: 110–120.
Cardesa A, Zidar N. Barnes L, Eveson J, Reichart P, Sidransky D, (editors). Verrucous carcinoma. World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. Lyon: IARC Press; 2005. 122–123.
Licitra L, Bernier J, Grandi C, Locati L. Cancer of the larynx. Crit Rev Oncol Hematol 2003; 47: 65–80.
Bodnar M, Rekwirowicz H, Burduk P. Impact of tobacco smoking on biologic background of laryngeal squamous cell carcinoma. Przegl Lek 2009; 66: 598–602.
Sawsan HK. Studing the Relationship between 5′-Nucleotidase Activity and Body Mass Index in Obese Individuals, Medical Journal of Babylon, 2009; 6:3–4.
Goodman M, Morgan RW, Ray R, Malloy CD, Zhao K. Cancer in asbestos-exposed occupational cohorts: a meta-analysis. Cancer Causes Control 1999; 10: 453–465.
Menvielle G, Luce D, Goldberg P. Smoking, alcohol drinking and cancer risk for various sites of the larynx and hypopharynx: a case-control study in France. Eur J Cancer Prev 2004; 13: 165–172.
Qadeer M, Colabianchi N, Strome M. Gastroesophageal reflux and laryngeal cancer. Am J Otolaryngol 2006; 27: 119–128.
Weinstein G, Laccourreye O, Brasnu D. Reconsidering a paradigm: the spread of supraglottic carcinoma to the glottis. Laryngoscope 1995; 105: 1129–1133.
Redaelli de Zinis L, Nicolai P, Tomenzoli D. The distribution of lymph node metastases in supraglottic squamous cell carcinoma: therapeutic implications. Head Neck 2002; 24:913–920.
César Gavilán, Javier Gavilán. Five-Year Results of Functional Neck Dissection for Cancer of the Larynx; Arch Otolaryngol Head Neck Surg. 1989; 115(10):1193–1196.
Maharjan R, Adhikari P, Khalilullah S, Sinha BK, Baskota DK. Early Complications of Total Laryngectomy: A Retrospective Study. Nepalese Journal of ENT- Head and Neck Surgery 2010; 1(2):17–18.
Conflicts of interest
About this article
Cite this article
El Tabbakh, M.T., Ahmed, M.R., Sedik, D.F. et al. Management of patients with cancer of the larynx in Suez Canal University Teaching Hospital: 5 years’ experience. Egypt J Otolaryngol 30, 30–33 (2014). https://doi.org/10.4103/1012-5574.127196
- cancer of the larynx
- Suez Canal