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The Egyptian Journal of Otolaryngology
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Management of patients with cancer of the larynx in Suez Canal University Teaching Hospital: 5 years’ experience

The Egyptian Journal of Otolaryngology volume 30, pages 30–33 (2014)Cite this article

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Abstract

Background

Suez Canal University Hospital, which is the only tertiary care facility in the Suez Canal and Sinai area, is estimated to service more than 5 million patients. Cancer of the larynx, which is the most common head and neck cancer, is also the most common tumor presented to the otolaryngology departments.

Aim

To evaluate the results of interventional protocols for patients with cancer of the larynx treated in Suez Canal University Hospital.

Patients and methods

This was a retrospective study carried out on 53 patients with cancer of the larynx reviewed from 1 January 2007 to 1 January 2012 according to demographic, clinical, radiological, operative, pathological data, and possible complications.

Results

Fifty-three patients, mean age 58 years (71.1% were from urban areas), were studied. The main presenting symptom was hoarseness of voice (66%). Glottis carcinoma was the most common type of cancer found in 41.1% patients.

Stage IVa was the most common presenting stage in 39.6% of the patients. Emergent tracheostomy was performed for 39.6% of the patients.

According to the treatment protocol, single treatment modality was recommended for 38 (71.6%) patients: 17 (32%) patients were recommended total laryngectomy, followed by radiotherapy in 11 (20.7%) patients, chemotherapy was recommended for eight (15.1%) patients, concurrent chemoradiotherapy was offered to one (1.9%) patient, and partial laryngectomy with preservation of both arytenoids was offered to one (1.9%) patient. In addition, 15 (28.4%) patients were subjected to combined therapy: total laryngectomy combined with radiotherapy in nine (17%) patients and total laryngectomy with chemoradiotherapy in six (11.4%) patients.

Conclusion

Although the standards of management of laryngeal carcinoma in Suez Canal University hospital are almost in compliance with regional and international standards, we need to deal with the time delay between the diagnosis and definitive treatment to revise the items in the medical records and its registration.

References

  1. Jemal A, Siegel R, Ward E. Cancer statistics, 2007. CA Cancer J Clin 2007; 57: 43–66.

    Article  Google Scholar 

  2. Farrington W, Weighill J, Jones P. Total laryngectomy for cancer of the larynx. J Laryngol Otol 1986; 100: 53–58.

    Article  CAS  Google Scholar 

  3. Marioni G, Marchese-Ragona R, Cartei GA. Current opinion in diagnosis and treatment of laryngeal carcinoma. Cancer Treat Rev 2006; 32: 504–515.

    Article  Google Scholar 

  4. Boring C, Squires T, Tong T. Cancer statistics. Cancer 1994; 44: 7–26.

    CAS  Google Scholar 

  5. Wake M. The urban/rural divide in head and neck cancer the effect of atmospheric pollution. Clin Otolaryngol 1993; 18: 298–302.

    Article  CAS  Google Scholar 

  6. William B, David E, Robert H. Malignant tumors of the larynx; anatomy and embryology [part 6, section 5, chapter 107 - paragrah 2]. Cummings otolaryngology - head and neck surgery. 5th ed. Washington University School of Medicine: Mosby; 2010; 2:1482

  7. Armstrong W, Netterville J. Anatomy of the larynx, trachea, and bronchi. Otolaryngol Clin North Am 1995; 28: 685–699.

    Article  CAS  Google Scholar 

  8. Frazer E. The development of the larynx. J Anat Physiol 1909; 44: 156.

    Google Scholar 

  9. Michael S, Erik S, Udo S, Lawrence MR, Edward DL, Markus V. Atlas of anatomy. Head and Neuroanatomy (THIEME Atlas of Anatomy) [Paperback], 1st Edition, 2010, p. 414.

  10. Michael G, George G, Martin J. Anatomy of the larynx. Scott-Brown’s Otorhinolaryngology Head and Neck Surgery [chapter 162]. 7th ed. Michael J Gleeson, George Browning, Martin J Burton, Ray C Clarke, John Hibbert, Nicholas Jones, et al. (Editors): Hodder Arnold: London; 2008; 2:2132.

    Google Scholar 

  11. Janfaza P, Nadol J, Galla R. Surgical anatomy of the head and neck [chapter 11]. Anatomy of the neck. Philadelphia: lippincott Williams & Wilkins; 2001.

    Google Scholar 

  12. Van de Graff W. Thoracic influence on upper airway patency. J Appl Physiol 1988; 65:2124–2131

    Article  Google Scholar 

  13. Sant’Ambrogio F, Mathew O, Clark W. Laryngeal influences on breathing pattern and posterior cricoarytenoid muscle activity. J Appl Physiol 1985; 58:1298–1304.

    Article  Google Scholar 

  14. Brancatisano T, Dodd D, Engel L. Respiratory activity of the posterior cricoarytenoid muscle and vocal cords in humans. J Appl Physiol 1984; 57: 1143–1149.

    Article  CAS  Google Scholar 

  15. Hagen P, Lyons G, Haindel C. Verrucous carcinoma of the larynx: role of human papilloma virus, radiation, and surgery. Laryngoscope 1993; 103: 253–257.

    Article  CAS  Google Scholar 

  16. Ferlito A, Altavilla G, Rinaldo A. Basaloid squamous cell carcinoma of the larynx and hypopharynx. Ann Otol Rhinol Laryngol 1997; 106: 1024–1035.

    Article  CAS  Google Scholar 

  17. Paulino A, Singh B, Shah J. Basaloid squamous cell carcinoma of the head and neck. Laryngoscope 2000; 110: 1479–1482.

    Article  CAS  Google Scholar 

  18. Thompson L, Wieneke J, Miettinen M. Spindle cell (sarcomatoid) carcinomas of the larynx. Am J Surg Pathol 2002; 26: 153–170.

    Article  Google Scholar 

  19. Cardesa A, Zidar N. Barnes L, Eveson JW, Reichart P, Sidransky D, (editors). Spindle cell carcinoma. World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. Lyon: IARC Press; 2005; 127–128.

  20. Koch B, Trask D, Hoffman H. National survey of head and neck verrucous carcinoma: patterns of presentation, care, and outcome. Cancer 2001; 92: 110–120.

    Article  CAS  Google Scholar 

  21. Cardesa A, Zidar N. Barnes L, Eveson J, Reichart P, Sidransky D, (editors). Verrucous carcinoma. World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. Lyon: IARC Press; 2005. 122–123.

  22. Licitra L, Bernier J, Grandi C, Locati L. Cancer of the larynx. Crit Rev Oncol Hematol 2003; 47: 65–80.

    Article  Google Scholar 

  23. Bodnar M, Rekwirowicz H, Burduk P. Impact of tobacco smoking on biologic background of laryngeal squamous cell carcinoma. Przegl Lek 2009; 66: 598–602.

    PubMed  Google Scholar 

  24. Sawsan HK. Studing the Relationship between 5′-Nucleotidase Activity and Body Mass Index in Obese Individuals, Medical Journal of Babylon, 2009; 6:3–4.

    Google Scholar 

  25. Goodman M, Morgan RW, Ray R, Malloy CD, Zhao K. Cancer in asbestos-exposed occupational cohorts: a meta-analysis. Cancer Causes Control 1999; 10: 453–465.

    Article  CAS  Google Scholar 

  26. Menvielle G, Luce D, Goldberg P. Smoking, alcohol drinking and cancer risk for various sites of the larynx and hypopharynx: a case-control study in France. Eur J Cancer Prev 2004; 13: 165–172.

    Article  CAS  Google Scholar 

  27. Qadeer M, Colabianchi N, Strome M. Gastroesophageal reflux and laryngeal cancer. Am J Otolaryngol 2006; 27: 119–128.

    Article  Google Scholar 

  28. Weinstein G, Laccourreye O, Brasnu D. Reconsidering a paradigm: the spread of supraglottic carcinoma to the glottis. Laryngoscope 1995; 105: 1129–1133.

    Article  CAS  Google Scholar 

  29. Redaelli de Zinis L, Nicolai P, Tomenzoli D. The distribution of lymph node metastases in supraglottic squamous cell carcinoma: therapeutic implications. Head Neck 2002; 24:913–920.

    Article  Google Scholar 

  30. César Gavilán, Javier Gavilán. Five-Year Results of Functional Neck Dissection for Cancer of the Larynx; Arch Otolaryngol Head Neck Surg. 1989; 115(10):1193–1196.

    Article  Google Scholar 

  31. Maharjan R, Adhikari P, Khalilullah S, Sinha BK, Baskota DK. Early Complications of Total Laryngectomy: A Retrospective Study. Nepalese Journal of ENT- Head and Neck Surgery 2010; 1(2):17–18.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Otolaryngology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

    Mohamed T. El Tabbakh, Mohamed R. Ahmed MD & Diaa El Hennawi

  2. Department of Otolaryngology, Ismailia General Hospital, Ismailia, Egypt

    Doaa F. Sedik

Authors
  1. Mohamed T. El Tabbakh
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  2. Mohamed R. Ahmed MD
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  3. Doaa F. Sedik
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  4. Diaa El Hennawi
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Correspondence to Mohamed R. Ahmed MD.

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El Tabbakh, M.T., Ahmed, M.R., Sedik, D.F. et al. Management of patients with cancer of the larynx in Suez Canal University Teaching Hospital: 5 years’ experience. Egypt J Otolaryngol 30, 30–33 (2014). https://doi.org/10.4103/1012-5574.127196

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  • DOI: https://doi.org/10.4103/1012-5574.127196

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