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Table 1 Table showing the review of cases previously reported in literature and their findings and outcomes

From: Osteosarcoma of the sphenoid sinus extending to ethmoid sinus—report of a rare case with review of literature giving special emphasis on treatment and outcome

S.No.

Author

Age/Sex

Prior radiation

Clinical presentation

Extent

Surgery

Approach

Histopathology/ Type

Immunohistochemistry

Chemotherapy

Radiotherapy

Recurrence

Follow up (months)

Outcome

1

Yamada et al (2012) [12]

75/F

Yes

Frontal headache

Sphenoid sinus

Yes, 3 times

Trans nasal endoscopic, Subtotal

NR

Vimentin +, High Ki 67, Anti cytokeratin -

Ifosfamide, Cisplatin, Etoposide

Yes

No

24

Alive

2

Gadwal et al (2001) [10]

9/M

No

Headache, lethargy

Sphenoid sinus, sella turcica erosion

Yes

NR

Grade 1

NR

No

Yes (4500 Gy)

Yes

8

Dead with locally extensive disease

3

Malalis et al (2013) [6]

18/F

No

Headache, vision loss

Sphenoid sinus, left cavernous sinus, compression of left optic nerve

Yes

Trans nasal endoscopic

Grade 2

NR

Cisplatin, Doxorubicin, Etoposide, Ifosfamide

No

NR

NR

NR

4

Huber et al (2008) [14]

52/M

Yes

NR

Sphenoid sinus

Yes

NR

High, fibroblastic

NR

Adriamycin, Cisplatin

No

Persistence

7

Dead

5

Geetha et al (1999) [13]

38/M

No

Diplopia, Obesity, decreased visual acuity

Sphenoid sinus, sellar, suprasellar extension

Yes

Subtotal resection

NR

NR

Adriamycin, Cisplatin, Holoxan

Yes 55 Gy

No

12

Alive

6

Chennupati et al (2008) [11]

14/F

No

Dysphagia, Hoarseness, diplopia, right cranial nerve 6, 10, 11, 12 palsy

Sphenoid sinus, clivus, hypoglossal canal, jugular foramen

No

N/A

High

Vimentin +, Cytokeratin -, Desmin -, smooth muscle actin -, neurofilament protein -

Cisplatin, Doxorubicin, Methotrexate, Etoposide, Ifosfamide

7000 cGy

NR

NR

NR

7

Ellison et al (1996) [16]

11/F

No

Left eye pain, left eye proptosis, vision loss, cranial nerve 6 palsy

Sphenoid sinus, pterygopalatine fossa, cavernous sinus, sella turcica, sphenoid bone, middle cranial fossa

Yes

Subtotal resection

Chondroblastic

S 100 +, Vimentin +, Actin -, Myoglobin -, cytokeratin -

Methotrexate, Leucovorin, Cisplatin, Adriamycin

Yes

NR

NR

NR

8

Guo et al (2017) [15]

55/F

No

Diplopia

Sphenoid sinus, clivus

Yes

Subtotal resection

NR

NR

Yes

Yes

No

5

Alive

9

Kachhara et al (1999) [9]

38/M

No

Diplopia, Cranial nerve 6 palsy

Sphenoid sinus, Sella, suprasellar, clivus

Yes

Frontobasal, Gross total

NR

NR

Cisplatin, Adriamycin, Ifosfamide

55 Gy

No

18

Alive

10

Mathkour et al (2016) [3]

29/M

No

Frontal headache

Sphenoid sinus, clivus

Yes

Trans nasal endoscopic, Gross total

High

NR

Yes

Yes

No

24

Alive

11

Patel et al (2011) [7]

44/F

Yes

NR

Sphenoid and ethmoid sinus, parasellar region, middle fossa

No

N/A

NR

NR

Yes

No

No

16

Alive

12

Yamada et al (2013) [8]

78/F

No

Frontal headache

Sphenoid, Ethmoid sinus, cavernous sinus

Yes

Trans nasal endoscopic, Subtotal resection

NR

NR

No

Marginal dose- 39 Gy

Site dose- 55 Gy

No

5

Alive

13

Mitra et al (2019) [4]

17/ F

No

Headache, hemifacial pain, epistaxis, anosmia

Sphenoid, ethmoid sinus

Yes

Trans nasal endoscopic

High

Vimentin +, SATB2 +, Osteopontin +, CD 99 +

Cisplatin, Doxorubicin

No

NR

NR

NR

14

Present case

19/M

No

Headache, nose block, blurred vision

Sphenoid sinus and ethmoid sinus

Yes

Trans nasal endoscopic, subtotal resection

Osteoblastic

SATB 2 +, Beta Catenin +

Cisplatin, Adriamycin, Ifosfamide

No

NR

3

NR