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Table 2 Comparison between the three drugs as regards changes in attack duration (hours), frequency (number/month), severity of headache (VAS), duration of vertiginous attack (hours), and its frequency (number/ month) before and after medical treatment (Kruskal–Wallis and one-way ANOVA tests)

From: Comparison between the effectiveness of three prophylactic drugs for vestibular migraine; cinnarizine, propranolol, and topiramate: prospective study

 

Mean ± SD

Range (min.–max.)

 

P value

Sig

Attack duration of headache

  

K

  

    Cinnarzine group

 − 0.30(± 0.53)

 − 0.98–1.00

1.38

0.502

NS

    Propranolol group

 − 0.04(± 0.39)

 − 0.96–0

    Topiramate group

0.91(± 4.11)

 − 0.98–11.00

Frequency of headache

  

F

  

    Cinnarzine group a,b

 − 0.17 (± 0.30)

 − 0.75–0

9.47

0.009

HS*

    Propranolol group b,a

 − 0.43 (± 0.36)

 − 0.95–0

    Topiramate group c,b

 − 0.55 (± 0.16)

 − 0.88–(− 0.25)

Severity of headache

  

F

  

    Cinnarzine group a,b

 − 24 (± .21)

 − .57–.13

3.59

0.036

S*

    Propranolol group b,a

 − 34 (± .17)

 − .56–.00

    Topiramate group c,b

 − 40 (± .13)

 − .60–(− .13)

Duration of vertiginous attacks

  

K

  

    Cinnarzine group

2.80 (± 12.27)

 − 1.00–47.0

3.78

0.151

NS

    Propranolol group

 − 0.57 (± 0.39)

 − 0.97–0

    Topiramate group

0.76 (± 0.34)

 − 1.00–0

Frequency of vertiginous attacks

  

F

  

    Cinnarzine group

 − 0.43 (± 0.39)

 − 0.97–0.33

0.48

0.621

NS

    Propranolol group

 − 0.53 (± 0.31)

 − 0.88–0

    Topiramate group

 − 0.55 (± 0.34)

 − 0.94–0

  1. Table 2 showed that Topiramate was superior to CIN in reducing the frequency and severity of headache attacks with significant differences between both drugs
  2. N.B: (a,b,c group have the same letters, there were no significant differences between them but have different letters there were significant differences between them. (Negative signal in mean is due to after treatment was lower than before treatment)