Table 2 The results of all questions of group A, subscales, and the total scores (Q question, V1 the first questionnaire fulfilling (1 week before therapy), V2 the second questionnaire fulfilling (the day of the first injection), V3 the third questionnaire fulfilling (the day of the second injection one; month after the first injection), V4 the forth questionnaire fulfilling (6 months after the first injection), ICC intra-class correlation coefficient, *significant p-value < 0.05)

Q1

Item 1

5.58 ± 1.63

5.29 ± 1.72

0.928

0.93

 < 0.0001*

2.89 ± 1.34

0.149

1.3 ± 0.53

7.964

 < 0.0001*

Item 2

5.81 ± 1.6

5.53 ± 1.63

0.915

0.915

 < 0.0001*

2.93 ± 1.15

0.629

1.24 ± 0.48

7.957

 < 0.0001*

Item 3

5.13 ± 1.19

5.3 ± 1.35

0.832

0.839

 < 0.0001*

2.59 ± 0.93

0.533

1.22 ± 0.84

8.009

 < 0.0001*

Item 4

4.86 ± 1.32

4.65 ± 1.21

0.869

0.869

 < 0.0001*

2.19 ± 0.87

0.506

1.18 ± 0.44

7.976

 < 0.0001*

Q2

Item 1

3.66 ± 1.19

3.52 ± 1.02

0.91

0.92

 < 0.0001*

2.66 ± 1.1

0.447

1.4 ± 0.74

7.851

 < 0.0001*

Item 2

3.8 ± 1.21

3.58 ± 1.14

0.895

0.897

 < 0.0001*

2.93 ± 1.06

0.602

1.3 ± 0.63

7.632

 < 0.0001*

Item 3

3.73 ± 1.39

3.6 ± 1.28

0.941

0.944

 < 0.0001*

3.04 ± 0.96

0.682

1.29 ± 0.61

7.471

 < 0.0001*

Item 4

3.47 ± 1.51

3.23 ± 1.34

0.919

0.926

 < 0.0001*

2.65 ± 1.02

0.622

1.22 ± 0.56

7.146

 < 0.0001*

Q3

4.93 ± 1.09

4.86 ± 1.07

0.971

0.971

 < 0.0001*

3.65 ± 1.15

0.89

1.83 ± 0.79

7.992

 < 0.0001*

Q4

5.39 ± 0.74

5.45 ± 0.76

0.95

0.951

 < 0.0001*

4.47 ± 0.9

0.783

2.71 ± 0.83

8.066

 < 0.0001*

Q5

3.22 ± 1.34

3.07 ± 1.34

0.965

0.965

 < 0.0001*

2.98 ± 1.23

0.879

2.05 ± 0.89

7.039

 < 0.0001*

Q6

3.52 ± 1.13

3.39 ± 1.06

0.932

0.933

 < 0.0001*

3.25 ± 1.06

0.757

2.19 ± 0.8

7.412

 < 0.0001*

Q7

3.41 ± 1.35

3.35 ± 1.34

0.984

0.984

 < 0.0001*

3.2 ± 1.29

0.924

2.07 ± 0.82

7.259

 < 0.0001*

Q8

2.34 ± 1.83

2.4 ± 1.91

0.992

0.993

 < 0.0001*

2.31 ± 1.85

0.964

1.52 ± 0.78

4.950

 < 0.0001*

Q9

5.91 ± 3.4

5.93 ± 0.26

0.918

0.92

 < 0.0001*

5.57 ± 0.56

0.843

2.95 ± 0.71

8.113

 < 0.0001*

Q10

3.81 ± 0.39

3.83 ± 0.37

0.921

0.922

 < 0.0001*

3.78 ± 0.41

0.78

1.67 ± 0.6

8.159

 < 0.0001*

Q11

3.83 ± 0.37

3.86 ± 0.35

0.911

0.913

 < 0.0001*

3.82 ± 0.38

0.792

1.83 ± 0.67

8.056

 < 0.0001*

Q12

2.64 ± 0.79

2.59 ± 0.76

0.962

0.962

 < 0.0001*

2.52 ± 0.75

0.828

1.31 ± 0.58

7.765

 < 0.0001*

Q13

2.93 ± 0.762

2.98 ± 0.81

0.943

0.945

 < 0.0001*

2.89 ± 0.81

0.834

1.08 ± 0.54

7.969

 < 0.0001*

Q14

3.81 ± 0.397

3.83 ± 0.37

0.921

0.922

 < 0.0001*

3.8 ± 0.406

0.811

1.73 ± 0.54

8.141

 < 0.0001*

Q15

3.88 ± 0.328

3.9 ± 0.29

0.878

0.882

 < 0.0001*

3.87 ± 0.34

0.728

1.76 ± 0.53

8.144

 < 0.0001*

Subscale 1

36.04 ± 4.72

34.7 ± 4.78

0.931

0.931

 < 0.0001*

21.88 ± 3.87

0.649

10.17 ± 2.38

7.92

 < 0.0001*

Subscale 2

16.23 ± 1.58

16.22 ± 1.58

0.97

0.971

 < 0.0001*

13.68 ± 1.75

0.89

7.49 ± 1.37

7.959

 < 0.0001*

Subscale 3

18.05 ± 2.97

17.77 ± 2.98

0.972

0.97

 < 0.0001*

17.16 ± 3.2

0.875

10.2 ± 1.62

7.93

 < 0.0001*

Subscale 4

15.33 ± 0.85

15.42 ± 0.82

0.886

0.87

 < 0.0001*

15.27 ± 0.89

0.868

7 ± 1.45

7.953

 < 0.0001*

Total score

85.63 ± 5.8

84.12 ± 5.86

0.942

0.942

 < 0.0001*

67.99 ± 5.23

0.729

34.87 ± 3.73

7.917

 < 0.0001*