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Table 2 Comparison between laryngeal symptoms among studied patients and the mean of each symptom in RSI score before and after treatment

From: Proton pump inhibitors as treatment of laryngeal disorders among patients with gastroesophageal reflux disease: a single-arm (pre and post) quasi-experimental study

Reflux symptoms and patient number

Baseline (n = 67)

Follow-up (n= 67)

P-value

Hoarseness: no.

56 (83%)

55 (82.1%)

0.819

 Mean ± SD

2.16 ± 1.33

1.45 ± 1.08

 

 Median (range)

3.0 (0.0–4.0)

1.0 (0.0–4.0)

0.000*

Clearing your throat: no.

67 (100%)

58 (86.6%)

0.003*

 Mean ± SD

3.00 ± 0.65

1.69 ± 1.52

 

 Median (range)

3.0 (2.0–4.0)

1.0 (0.0–5.0)

0.000*

Postnasal drip: no.

67 (100%)

51(76.1%)

0.000*

 Mean ± SD

2.91 ± 0.73

1.55 ± 1.48

 

 Median (range)

3.0 (2.0–5.0)

1.0 (0.0–5.0)

0.000*

Difficulty swallowing food, liquid, and pills: no.

36 (53.7%)

17 (25.4%)

0.001*

 Mean ± SD

0.45 ± 0.88

1.03 ± 1.37

 

 Median (range)

0.0 (0.0–3.0)

1.0 (0.0–5.0)

0.007*

Coughing after you eat or lying down: no.

66 (98.5%)

35 (52.2%)

0.000*

 Mean ± SD

2.45 ± 0.80

1.36 ± 1.73

 

 Median (range)

3.0 (0.0–4.0)

1.0 (0.0–5.0)

0.000*

Breathing difficulties or choking episodes: no.

33 (49.4%)

30 (44.8%)

0.604

 Mean ± SD

0.94 ± 1.11

0.76 ± 0.92

 

 Median (range)

0.0 (0.0–3.0)

0.0 (0.0–3.0)

0.319

Troublesome or annoying cough: no.

50 (74.6%)

35 (52.2%)

0.007*

 Mean ± SD

2.01 ± 1.64

1.16 ± 1.25

 

 Median (range)

2.0 (0.0–5.0)

1.0 (0.0–4.0)

0.000*

Sensation of something sticking in your throat: no.

65 (97%)

45 (67.2%)

0.000*

 Mean ± SD

3.22 ± 1.20

1.39 ± 1.45

 

 Median (range)

3.0 (0.0–5.0)

1.0 (0.0–5.0)

0.000*

Heartburn chest pain indigestion or stomach acid coming up: no.

56 (83.6%)

41 (61.2%)

0.004*

 Mean ± SD

2.69 ± 1.55

1.21 ± 1.30

 

 Median (range)

3.0 (0.0–5.0)

1.0 (0.0–5.0)

0.000*

Reflux Symptom Index

 Mean ± SD

19.84 ± 4.96

11.94 ± 10.61

 

 Median (range)

19.0 (14.0–32.0)

7.0 (4.0–36.0)

0.000*