From: COVID-19-related acute invasive fungal rhinosinusitis: risk factors associated with mortality
Variable | All patients (n = 54) | Survived (n = 33) | Died (n = 21) | P value |
---|---|---|---|---|
Sex |  |  |  | 0.851†|
 Females | 24 (44.4%) | 15 (45.5%) | 9 (42.9%) |  |
 Males | 30 (55.6%) | 18 (54.5%) | 12 (57.1%) |  |
Comorbidity | Â | Â | Â | Â |
 Chronic kidney disease | 10 (18.5%) | 7 (21.2%) | 3 (14.3%) | 0.723‡ |
 Chronic liver disease | 2 (3.7%) | 0 (0.0%) | 2 (9.5%) | 0.147‡ |
 Hematological malignancy | 2 (3.7%) | 0 (0.0%) | 2 (9.5%) | 0.147‡ |
 History of thromboembolism | 9 (17.0%) | 6 (18.2%) | 3 (15.0%) | 1.000‡ |
 Diabetes mellitus | 52 (96.3%) | 33 (100.0%) | 19 (90.5%) | 0.147‡ |
The onset of diabetes mellitus |  |  |  | 0.694‡ |
 Newly diagnosed | 8 (15.4%) | 6 (18.2%) | 2 (10.5%) |  |
 Previously diagnosed | 44 (84.6%) | 27 (81.8%) | 17 (89.5%) |  |
Glycemic control | Â | Â | Â | Â |
 Diabetic ketoacidosis event | 34 (63.0%) | 21 (63.6%) | 13 (61.9%) | 0.898†|
 Poor glycemic control in hospital | 17 (31.5%) | 9 (27.3%) | 8 (38.1%) | 0.404†|
COVID-19 PCR positivity |  |  |  | 0.653†|
Recent within 2 weeks | 20 (37.0%) | 13 (39.4%) | 7 (33.3%) | Â |
Previous within 2 months | 34 (63.0%) | 20 (60.6%) | 14 (66.7%) | Â |
Implicated pathogen |  |  |  | 0.329‡ |
 Mucoraceae | 42 (77.8%) | 24 (72.7%) | 18 (85.7%) |  |
 Aspergillus | 12 (22.2%) | 9 (27.3%) | 3 (14.3%) |  |
Extent of disease | Â | Â | Â | Â |
 Sinonasal tissue infarction | 54 (100.0%) | 33 (100.0%) | 21 (100.0%) | NA |
 Skin infarction | 25 (46.3%) | 15 (45.5%) | 10 (47.6%) | 0.876†|
 Intraorbital extension | 38 (70.4%) | 20 (60.6%) | 18 (85.7%) | 0.049†|
 Intracranial extension | 22 (40.7%) | 10 (30.3%) | 12 (57.1%) | 0.050†|
Severity of pulmonary affection |  |  |  | 0.796§ |
 No lung affection | 7 (13.0%) | 5 (15.2%) | 2 (9.5%) |  |
 Mild | 22 (40.7%) | 13 (39.4%) | 9 (42.9%) |  |
 Moderate | 7 (13.0%) | 4 (12.1%) | 3 (14.3%) |  |
 Severe | 18 (33.3%) | 11 (33.3%) | 7 (33.3%) |  |
Debridement technique | All debrided patients (n = 52) | Survived (n = 32) | Died (n = 20) | 0.606†|
 Endoscopic | 19/52 (36.5%) | 10/32 (31.25%) | 9/20 (45.0%) |  |
 Combined endoscopic and external | 33/52 (63.5%) | 22/32 (68.75%) | 11/20 (55.0%) |  |