Table 2 Uni- and multivariable Cox proportional hazard models for predictors of all-cause, cancer-specific mortality in the analytic cohort

Age at diagnosis

1.019

1.014–1.023

<0.001

1.023

1.019–1.028

<0.001

1.014

1.009–1.019

<0.001

1.020

1.014–1.025

<0.001

 Male

1

Ref

1

Ref

1

Ref

1

Ref

 Female

1.006

0.905–1.118

0.914

0.984

0.88–1.101

0.779

0.998

0.882–1.13

0.977

0.999

0.877–1.138

0.984

Year of diagnosis

0.980

0.966–0.994

0.004

0.980

0.966–0.994

0.006

0.976

0.96–0.991

0.002

0.974

0.959–0.99

0.001

 White

1

Ref

1

Ref

1

Ref

1

Ref

 Black

1.527

1.378–1.693

<0.001

1.341

1.206–1.492

<0.001

1.567

1.393–1.763

<0.001

1.333

1.181–1.506

<0.001

 Others

0.912

0.762–1.092

0.318

0.881

0.735–1.057

0.172

0.946

0.77–1.162

0.594

0.935

0.76–1.152

0.529

 Married

1

Ref

1

Ref

1

Ref

1

Ref

 Single

1.589

1.432–1.763

<0.001

1.468

1.315–1.64

<0.001

1.641

1.455–1.851

<0.001

1.422

1.251–1.616

<0.001

 Divorced/separated

1.367

1.216–1.538

<0.001

1.331

1.182–1.5

<0.001

1.420

1.239–1.628

<0.001

1.340

1.166–1.538

<0.001

 Widowed

2.054

1.791–2.355

<0.001

1.528

1.317–1.773

<0.001

2.033

1.733–2.384

<0.001

1.553

1.306–1.847

<0.001

 Unknown

1.114

0.878–1.414

0.375

1.063

0.835–1.352

0.621

1.234

0.948–1.607

0.119

1.167

0.893–1.524

0.258

 Pyriform sinus

1

Ref

1

Ref

1

Ref

1

Ref

 Post-cricoid region

1.046

0.809–1.353

0.731

1.024

0.789–1.328

0.860

1.211

0.918–1.597

0.176

1.220

0.921–1.615

0.165

 Aryepiglottic fold

0.771

0.645–0.922

0.004

0.796

0.663–0.955

0.014

0.648

0.517–0.811

<0.001

0.715

0.569–0.899

0.004

 Posterior wall of the hypopharynx

1.150

0.974–1.358

0.099

1.238

1.045–1.466

0.013

1.066

0.875–1.3

0.525

1.203

0.983–1.472

0.073

 Overlapping lesion

1.182

0.942–1.482

0.148

1.129

0.899–1.418

0.297

1.179

0.907–1.531

0.218

1.126

0.865–1.465

0.379

 Not otherwise specified

1.147

1.041–1.263

0.006

1.100

0.997–1.213

0.058

1.170

1.047–1.308

0.006

1.116

0.997–1.249

0.057

 T1

1

Ref

1

Ref

1

Ref

1

Ref

 T2

1.496

1.266–1.768

<0.001

1.424

1.203–1.686

<0.001

1.694

1.365–2.103

<0.001

1.597

1.284–1.986

<0.001

 T3

1.907

1.595–2.28

<0.001

1.951

1.625–2.341

<0.001

2.425

1.935–3.039

<0.001

2.398

1.905–3.017

<0.001

 T4

2.561

2.171–3.021

<0.001

2.476

2.09–2.932

<0.001

3.479

2.817–4.298

<0.001

3.239

2.612–4.018

<0.001

 N0

1

Ref

1

Ref

1

Ref

1

Ref

 N1

1.083

0.961–1.22

0.191

1.283

1.134–1.451

<0.001

1.168

1.011–1.35

0.034

1.356

1.169–1.574

<0.001

 N2

1.217

1.101–1.346

<0.001

1.455

1.306–1.622

<0.001

1.458

1.293–1.644

<0.001

1.679

1.477–1.91

<0.001

 N3

1.736

1.436–2.098

<0.001

2.259

1.855–2.752

<0.001

2.135

1.724–2.645

<0.001

2.683

2.146–3.353

<0.001

 Well differentiated; grade I

1

Ref

1

Ref

1

Ref

1

Ref

 Moderately differentiated; grade II

0.990

0.801–1.225

0.928

0.904

0.729–1.121

0.356

0.954

0.749–1.215

0.703

0.860

0.673–1.098

0.226

 Poorly differentiated; grade III

0.879

0.708–1.09

0.240

0.783

0.629–0.975

0.029

0.872

0.682–1.115

0.274

0.766

0.597–0.984

0.037

 Undifferentiated; anaplastic; grade IV

0.845

0.531–1.345

0.478

0.957

0.6–1.525

0.852

0.841

0.496–1.427

0.522

0.954

0.561–1.622

0.861

 Unknown

0.857

0.684–1.074

0.181

0.750

0.596–0.943

0.014

0.786

0.607–1.017

0.067

0.686

0.527–0.892

0.005

 Performed

1

Ref

1

Ref

1

Ref

1

Ref

 Not performed

1.406

1.262–1.565

<0.001

1.602

1.431–1.793

<0.001

1.461

1.287–1.66

<0.001

1.678

1.469–1.917

<0.001

 Unknown

1.378

0.905–2.097

0.135

1.158

0.757–1.769

0.499

1.680

1.068–2.644

0.025

1.454

0.92–2.296

0.109

 Performed

1

Ref

1

Ref

1

Ref

1

Ref

 No/unknown

2.096

1.896–2.317

<0.001

1.882

1.684–2.104

<0.001

2.104

1.872–2.364

<0.001

1.932

1.696–2.199

<0.001

 Performed

1

Ref

1

Ref

1

Ref

1

Ref

 No/unknown

1.437

1.317–1.569

<0.001

1.472

1.327–1.634

<0.001

1.342

1.21–1.488

<0.001

1.459

1.29–1.649

<0.001