Table 1 Demographic, clinic pathologic, and therapeutic features of 4068 patients across all selected primary sites
Characteristic | All patients (N = 4068), n (%) |
|---|---|
Age at diagnosis, median (IQR) | 62.0 (55.8, 70.0) |
Gender, n (%) | |
Male | 3346 (82.3%) |
Female | 722 (17.7%) |
Year of diagnosis, median (IQR) | 2009 (2006, 2012) |
Race | |
White | 3064 (75.3%) |
Black | 738 (18.1%) |
Others | 266 (6.5%) |
Marital status | |
Married | 1845 (45.4%) |
Single | 1000 (24.6%) |
Divorced/separated | 677 (16.6%) |
Widowed | 380 (9.3%) |
Unknown | 166 (4.1%) |
Primary site | |
Pyriform sinus | 2146 (52.8%) |
Post-cricoid region | 106 (2.6%) |
Aryepiglottic fold | 280 (6.9%) |
Posterior wall of the hypopharynx | 264 (6.5%) |
Overlapping lesion | 139 (3.4%) |
Not otherwise specified | 1133 (27.9%) |
Stage (6th AJCC) | |
I | 131 (3.2%) |
II | 402 (9.9%) |
III | 678 (16.7%) |
IVB | 465 (11.4%) |
IVC | 352 (8.7%) |
IVNOS | 208 (5.1%) |
T stage | |
T0 | 5 (0.1%) |
T1 | 370 (9.1%) |
T2 | 1378 (33.9%) |
T3 | 724 (17.8%) |
T4 | 1407 (34.6%) |
TX | 184 (4.5%) |
N stage | |
N0 | 1018 (25.0%) |
N1 | 851 (20.9%) |
N2 | 1900 (46.7%) |
N3 | 250 (6.1%) |
NX | 49 (1.2%) |
M stage | |
M0 | 3639 (89.5%) |
M1 | 352 (8.7%) |
MX | 77 (1.9%) |
Laterality | |
Unilateral | 642 (15.8%) |
Bilateral | 7 (0.2%) |
Paired | 3 (0.1%) |
Unpaired | 3416 (84.0%) |
Grade | |
Well differentiated; grade I | 157 (3.9%) |
Moderately differentiated; grade II | 1695 (41.7%) |
Poorly differentiated; grade III | 1359 (33.4%) |
Undifferentiated; anaplastic; grade IV | 45 (1.1%) |
Unknown | 812 (20.0%) |
Laterality | |
Unilateral | 642 (15.8%) |
Bilateral | 7 (0.2%) |
Unpaired | 3416 (84.0%) |
Paired | 3 (0.1%) |
Months of follow-up, median (IQR) | 17.0 (7.0, 42.0) |
SEER cause-specific death | |
No | 2005 (49.3%) |
Yes | 2063 (50.7%) |
Vital status at study cutoff | |
Alive | 1344 (33.0%) |
Death | 2724 (67.0%) |
Radiation | |
Performed | 3222 (79.2%) |
No/unknown | 846 (20.8%) |
Surgery | |
Performed | 759 (18.7%) |
Not performed | 3266 (80.3%) |
Unknown | 43 (1.1%) |
Chemotherapy | |
Performed | 2830 (69.6%) |
No/unknown | 1238 (30.4%) |
Radiation sequence | |
Pre-surgery | 109 (2.7%) |
Post-surgery | 930 (22.9%) |
Pre- and post-surgery | 16 (0.4%) |
Others | 3013 (74.1%) |