Clinical outcomes and impact of prognostic factors following adjuvant radiotherapy in oral tongue cancer patients

The Egyptian Journal of Otolaryngology

Table 4 Impact of prognostic factors on overall survival (OS) in study cohort (N = 144)

Covariates	No. of patients	5-year OS	Median OS	Univariate analysis p value	Multivariate analysis H.R. (95% C.I.) p value
*Age*
≤ 45 years	76	66%	NR	0.04	1.98 (1.15–3.4)
> 45 years	68	48%	52 months		0.01
*Grade*
Low	108	62%	99 months	0.33
High	20	47%	52 months
*PNI*
Absent	82	67%	99 months	0.01	1.96 (1.14–3.4)
Present	41	43%	25 months		0.01
*ECE*
Absent	102	62%	99 months	0.19
Present	33	50%	56 months
*DOI*
≤ 10 mm	69	66%	99 months	0.13
> 10 mm	57	56%	52 months
*Node metastasis (pN)*
Negative (pN-ve)	69	70%	NR	0.02	1.6 (1.0–2.8)
Positive (pN+ve)	72	47%	54 months		0.07
*Stage (AJCC 7*^th)
Early	47	72%	NR	0.05	1.24(0.53–2.9)
Locally Advanced	95	51%	68 months		0.62

PNI perineural invasion; ECE extra-capsular extension; DOI depth of invasion; NR not reached
Analysis of histological features was based on available pathology slides and blocks (number of patients provided)